SynthesisJournal of orthopaedic surgery and research2025
The effect of platelet-rich plasma on clinical outcomes within two years after anterior cruciate ligament reconstruction: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Effect of platelet-rich plasma on pain, function, and graft maturation after anterior cruciate ligament reconstruction: a prospective, randomized controlled trial.Scientific reports · 2026Trial
- Efficacy of Intra-Articular Injection of Platelet-Rich Plasma and Growth Factor Concentrate in Degenerative Meniscal Lesions.Journal of orthopaedic case reports · 2026Article
- Toward Standardized Platelet-Rich Plasma Therapy in Tendon Healing: Integrating Biological Characterization with Clinical Translation.International journal of molecular sciences · 2026Review
- Osteoinductive and Biocompatibility Assessment of a 3D-Printed Polymeric-Hydroxyapatite Composite Interference Screw.Polymers · 2026Article
- Next-generation strategies for anterior cruciate ligament repair: constructing biointelligent ligament grafts integrating biomimetic design, immune modulation, and sensory feedback.Frontiers in bioengineering and biotechnology · 2026Review
- Treatment options for concomitant cartilage damage in the anterior cruciate ligament (ACL)-injured athlete.Annals of joint · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAlthough platelet-rich plasma (PRP) has been applied in anterior cruciate ligament reconstruction (ACLR) to promote recovery, the time-dependent efficacy of PRP on postoperative pain, function, and joint stability remains controversial. This study aims to evaluate the clinical effects of PRP at various follow-up intervals within two years after ACLR through a time-stratified meta-analysis.
methodsA comprehensive literature search was systematically performed across PubMed, Embase, the Cochrane Library, and Web of Science databases. Outcome measures included the Visual Analogue Scale (VAS), Lysholm score, International Knee Documentation Committee (IKDC) score, Tegner activity score, and KT-1000 arthrometer readings. Standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs) were calculated. Sensitivity analyses were conducted to assess the stability and reliability of the findings.
resultsA total of 12 randomized controlled trials (RCTs) involving 599 ACLR patients were included. The analysis showed that PRP significantly improved VAS scores at 6 months postoperatively (SMD = -0.36, 95% CI: -0.62 to -0.10, P = 0.006), but no significant improvements were observed at 3, 12, or 24 months (P >0.05). Regarding knee function, there were no significant differences between groups in IKDC score, Lysholm score, or Tegner score at any of the assessed time points (3, 6, and 12 months) (P >0.05). Additionally, PRP significantly improved KT-1000 scores (SMD = -0.51, 95% CI: -0.82 to -0.19, P = 0.001).
conclusionsPRP may alleviate pain and improve knee joint stability in the short term (at 6 months post-ACLR), but it offers no significant benefits for mid- to long-term pain control or functional recovery. Future studies with standardized PRP preparation protocols, extended follow-up durations, and larger sample sizes are needed to further validate its clinical value.
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