Evidence map›Paper›PMID 41272803›Full record

ArticleClinical epigenetics2025

Distinct DNA methylation in mother-infant dyads exposed to PM2.5 in pregnancy.

Eleanor Klibaner-Schiff, Elisabeth M Simonin, Abhinav Kaushik, Youn Soo Jung, Xiaoying Zhou, Emma Thompson, R Sharon Chinthrajah, Mary M Johnson, Kari C Nadeau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eleanor Klibaner-SchiffDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, USA.
Elisabeth M SimoninDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, USA.
Abhinav KaushikDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, USA.
Youn Soo JungDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, USA.
Xiaoying ZhouDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, USA.
Emma ThompsonDepartment of Human Genetics, University of Chicago, 920 E 58th St, Chicago, IL, 60637, USA.
R Sharon ChinthrajahSean N. Parker Center for Allergy and Asthma, Stanford University, 750 Welch Rd Ste 114, Stanford, CA, 94304, USA.
Mary M JohnsonDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, USA.
Kari C NadeauDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, USA. knadeau@hsph.harvard.edu.

Funding

Immune Tolerance Dysfunction in Pregnancy due to Ambient Air Pollution ExposureR01ES032253 · NIEHS · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2020 to 2024
$2.2M
NIEHS NIH HHS R01 ES032253NIEHS NIH HHS R01 ES032253-01
6 · The paper itself

Abstract

Air pollution exposure during pregnancy increases the risk of allergic and respiratory diseases, yet its epigenetic effects across the maternal-fetal interface remain poorly understood. We conducted a pilot study of 10 mother-infant dyads near Fresno, California, to investigate whether prenatal air pollution exposure is associated with differential DNA methylation (DNAm) in maternal peripheral blood mononuclear cells (PBMCs) and infant cord blood mononuclear cells (CBMCs). Using a custom DNAm array targeting high-value allergy- and asthma-associated loci, we identified 24 CpG sites in maternal PBMCs and 18 in infant CBMCs associated with PM2.5 exposure. Only one CpG site was shared between PBMCs and CBMCs, suggesting largely distinct DNAm responses to PM2.5 in maternal and fetal circulations. Further research is needed to validate these associations and determine their functional implications for immune development and disease risk.

Indexed as

DNA MethylationMaternal ExposureParticulate MatterPrenatal Exposure Delayed EffectsAdultAir PollutionAsthmaCaliforniaCpG IslandsEpigenesis, GeneticFemaleFetal BloodHumansInfantInfant, NewbornLeukocytes, MononuclearParticulate MatterAllergy and asthmaDNA methylationMaternal–fetal interfacePregnancyPrenatal air pollution

Identifiers

PMID41272803
PMCPMC12639737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.