Evidence map›Paper›PMID 41272801›Full record

ReviewCell communication and signaling : CCS2025

The cellular economy while crafting regulatory processes relies on protein intrinsic disorder: how and why precision comes at a cost in protein structure.

Munishwar Nath Gupta, Vladimir N Uversky

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Munishwar Nath GuptaDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi, India.
Vladimir N UverskyDepartment of Molecular Medicine, Morsani College of Medicine, USF Health Byrd Alzheimer's Research Institute, University of South Florida, Tampa, FL, USA. vuversky@usf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory proteins, including those involved in signal transduction, invariably have intrinsic disorder. Enzymes, on the other hand, rely on unique structures for their pre-formed active sites to carry out catalysis. Disorder-promoting amino acids are shown to be non-essential amino acids, for which there are minimum biosynthetic costs. Therefore, disorder costs less to cells.

Indexed as

Intrinsically Disordered ProteinsAmino AcidsAnimalsHumansProtein ConformationSignal TransductionAmino AcidsIntrinsically Disordered ProteinsEnzyme active sitesEssential amino acidsGlycolytic enzymesMoonlighting proteinsNon-essential amino acidsProtein biosynthesisProtein evolution

Identifiers

PMID41272801
PMCPMC12751995

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.