ReviewStem cell research & therapy2025
Periodontal ligament stem cells in tissue remodeling: from mechanical forces to inflammatory signals.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Differential Transcriptomic and Adhesion Responses of Human Periodontal Ligament Cells to Cyclic and Static Hydrostatic Pressure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- Mechanobiology and Molecular Regulation of Periodontal Tissue Remodeling During Orthodontic Tooth Movement: From Periodontal Phenotype to Precision Orthodontics-A Narrative Review.International journal of molecular sciences · 2026Review
- Palm Mixed-Carotenes Modulate Viability, Wound Closure and Osteoprotegerin mRNA Expression in Human Periodontal Ligament Stem Cells.Biomedicines · 2026Article
- Non-Invasive Physical Plasma Regulates COX-2 via EP2/EP4 Expression in Periodontal Ligament Cells Under Inflammatory Conditions.International journal of molecular sciences · 2026Article
- PIEZO1 mediates orthodontic tension force-induced alveolar bone remodeling via the Ca²⁺/YAP-TAZ pathway in periodontal ligament stem cells.Journal of translational medicine · 2026Article
- HELLS Reduction Contributes to Compressive Force-Induced Functional Changes in PDLSCs.International journal of molecular sciences · 2026Article
- Arginine Methylation Antagonizes TEAD3-Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2-Sequestrating Condensates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Molecular Investigation of the Effects of Two Antiepileptic Drugs (Valproic Acid and Levetiracetam) on Alveolar Bone Under Orthodontic Force.Medicina (Kaunas, Lithuania) · 2026Article
- N-acetylcysteine restores osteogenesis in human periodontal ligament stem cells by attenuating HIF-1α-driven oxidative stress and glycolytic reprogramming.Journal of dental sciences · 2026Article
- Statin-loaded carbonated hydroxyapatite nanoemulsion controls matrix metalloproteinase-1 activity to enhance post-orthodontic stability in rats.Journal of applied oral science : revista FOB · 2026Article
- Substrate stiffness modulates human gingival fibroblast paracrine signaling to promote osteogenic differentiation of human periodontal ligament cells.Frontiers in bioengineering and biotechnology · 2026Article
- BMP4 dose dictates lineage specification bias in human periodontal ligament stem cells.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The periodontal ligament (PDL), a specialized fibrous connective tissue bridging cementum and alveolar bone, harbors periodontal ligament stem cells (PDLSCs) as its key regenerative cellular component. Within the oral cavity, PDLSCs are continually exposed to two predominant stimuli: mechanical forces and inflammatory signals. Under physiological conditions, PDLSCs experience cyclic loading forces during normal mastication. During orthodontic treatment, controlled mechanical force stimulates PDLSCs and mediates tooth movement. However, in pathological scenarios, pathological mechanical stress, whether from occlusal trauma or excessive orthodontic forces, can induce PDL damage, potentially leading to adverse outcomes such as root resorption or pathological alveolar bone loss. Additionally, bacterially-induced inflammation can trigger destructive PDL changes, including alveolar bone and soft tissue degradation. Crucially, PDLSCs serve as central regulators of both the pathogenesis and therapeutic resolution of these processes. This review comprehensively summarizes the modulatory roles of PDLSCs in alveolar bone remodeling under mechanical stimulation and inflammatory conditions. It covers the alterations in the biological properties and functions of PDLSCs, along with their interactions with other bone remodeling-related cells and the microenvironment. Moreover, this review emphasizes the mechanisms by which PDLSCs regulate alveolar bone remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.