Evidence map›Paper›PMID 41272785›Full record

ArticleStem cell research & therapy2025

Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism.

Juhi Jaiswal, Qingguo Zhao, Arash Shahsavari, Mohammad Jasim Ibrahim, Ethan Chang, Yu Zhang, Victor Yu, Ronald Zheng, Emma Wewel, Thomas Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juhi Jaiswal *Cell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Qingguo Zhao *Cell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Arash ShahsavariCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Mohammad Jasim IbrahimCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Ethan ChangCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Yu ZhangCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Victor YuCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Ronald ZhengCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Emma WewelCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Thomas ChenCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA.
Courtney L BaetgeDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.
Michael A DeveauDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.
Fei LiuCell Biology and Genetics Department, College of Medicine, Health Science Center, Texas A&M University, 206 Olsen Blvd, 242B Reynolds Medical Bldg., College Station, TX, 77843- 1114, USA. fliu@tamu.edu.

Funding

Roles of resident macrophages in salivary gland development, homeostasis, regeneration, and function restoration after radiotherapyR01DE031478 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LIU, FEI · 2021 to 2025
$1.8M
Therapeutic mechanisms of iPSC-MSC derived extracellular vesicles on dry mouth caused by Sjorgren's syndrome or radiotherapyR01DE032028 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Ryang Hwa Lee, Fei Liu · 2025 to 2026
$1.3M
Therapeutic mechanisms of iPSC-MSC derived extracellular vesicles on dry mouth caused by Sjorgren's syndrome or radiotherapyR56DE032028 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LEE, RYANG HWA, LIU, FEI · 2022 to 2022
$360k
NIDCR NIH HHS R01 DE031478NIDCR NIH HHS R01 DE032028NIDCR NIH HHS R56 DE032028NIH HHS 1R56DE032028
6 · The paper itself

Abstract

Radiation therapy of head and neck cancers frequently leads to irreversible dry mouth that severely compromises the quality of life and is difficult to remedy. Mesenchymal stem cells (MSCs) could ameliorate this adverse effect, but their application is limited by high variations of conventional tissue-derived MSCs and many practical challenges of cell therapies. This study investigated the potential of extracellular vesicles (EVs) from standardized MSCs derived from iPS cells (iMSCs) in ameliorating radiation-caused dry mouth. In a mouse model, locally injected young but not aging iMSC-EVs after radiation preserved saliva secretion and acinar structures. Mechanistically, young iMSC-EVs reversed the acute inhibition of physiological inflammation and chronic increase of pathogenic inflammation in radiated salivary glands, which is related to the preservation of tissue-resident macrophages and polarization of infiltrated macrophages. At both acute and chronic phase after radiation, iMSC-EVs enhanced mitochondria-related cell metabolism pathways such as Oxidative Phosphorylation that modulate cell survival and macrophage polarization. OXPHOS-promoting protein eIF5A and spermidine required for functional eIF5A hypusination are much richer in effective young iMSC-EVs compared with inert aging EVs. Moreover, young iMSC-EV treatment increased hypusinated eIF5A in radiated salivary glands, especially in macrophages. These findings together indicated that iMSC-EVs are a promising cell-free product to restore salivary gland function impaired by radiation, which is mediated by maintaining immune balance and mitochondria-related cell metabolism at both acute and chronic phases.

Indexed as

Extracellular VesiclesMesenchymal Stem CellsXerostomiaAnimalsHumansMacrophagesMaleMiceMice, Inbred C57BLSalivary GlandsCell metabolismExtracellular vesiclesiPS cellsMacrophagesMesenchymal stem cellsRadiation damageRegenerative inflammationSalivary glands

Identifiers

PMID41272785
PMCPMC12636160

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.