Evidence map›Paper›PMID 41272740›Full record

ArticleClinical epigenetics2025

SETD3 regulates Bcl-6 expression and Tfh differentiation in SLE CD4

Shu Ding, Shengjie Xue, Yu Rao, Ling-Xue Hu, Jie-Yue Liao

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Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Shu DingDepartment of Dermatology, The Third Xiangya Hospital of Central South University, #138 Tong Zipo Road, Changsha, 410013, Hunan, China.
Shengjie XueDepartment of Dermatology, The Second Xiangya Hospital of Central South University, #139 Renmin Middle Road, Changsha, 410011, Hunan, China.
Yu RaoDepartment of Dermatology, The Third Xiangya Hospital of Central South University, #138 Tong Zipo Road, Changsha, 410013, Hunan, China.
Ling-Xue HuDepartment of Dermatology, The Third Xiangya Hospital of Central South University, #138 Tong Zipo Road, Changsha, 410013, Hunan, China.
Jie-Yue LiaoDepartment of Dermatology, The Second Xiangya Hospital of Central South University, #139 Renmin Middle Road, Changsha, 410011, Hunan, China. dr.jieyueliao@csu.edu.cn.

Funding

National Natural Science Foundation of China Grant No. 81972921National Natural Science Foundation of China Grant No.82073448
6 · The paper itself

Abstract

backgroundTfh cells play a crucial role in the pathogenesis of SLE. Our previous research confirmed that SETD3, which is upregulated in CD4

resultsOur results demonstrated that SETD3 maintained a high level of expression throughout the differentiation process of Tfh cells. Moreover, following the interference with SETD3 expression, the expression of Bcl-6 and the differentiation of Tfh cells were notably impeded. SETD3 mediates the H3K4me3/K36me3 and H3K9ac/K14ac modifications of Bcl-6 promoter by interacting with NSD3, SMYD2, p300 and CBP, thereby upregulating Bcl-6 expression in Tfh differentiation. In addition, we also confirmed that the levels of H3K4me3/K36me3 and H3K9ac/K14ac in Bcl-6 promoter of SLE CD4

conclusionsElevated SETD3 expression in SLE CD4

Indexed as

Histone-Lysine N-MethyltransferaseHistonesLupus Erythematosus, SystemicProto-Oncogene Proteins c-bcl-6AcetylationAdultCD4-Positive T-LymphocytesCell DifferentiationFemaleGene Expression RegulationHumansMaleMethylationPromoter Regions, GeneticBCL6 protein, humanHistone-Lysine N-MethyltransferaseHistonesProto-Oncogene Proteins c-bcl-6Bcl-6Histone modificationSETD3SLETfh

Identifiers

PMID41272740
PMCPMC12639795

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.