ArticleCardiovascular diabetology. Endocrinology reports2025
Advanced age and elevated cholesterol predict diabetic neuropathy in patients with type II diabetes mellitus in Southern Ethiopia.
Article in Cardiovascular diabetology. Endocrinology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic neuropathy is the debilitating most common and expensive complication of diabetes that can cause significant mortality and morbidity, resulting from foot ulceration, lower extremity amputation, and pain that reduces the quality of life. The majority of type II diabetes mellitus patients continue to develop diabetic neuropathy despite optimal glycemic control, and the identification of predictors for diabetic neuropathy is important. Thus, this study aimed to determine the predictors of diabetic neuropathy in patients with type II diabetes mellitus in Ethiopia.
methodsA hospital-based retrospective longitudinal follow-up study was conducted from January 2012 to December 2021 in patients with type II diabetes. Simple random sampling was used to select study participants, and data were collected by reviewing the medical records. Stata version 14 was used for the statistical analysis. A bivariable and multivariable Cox regression analysis was performed to identify predictors of diabetic neuropathy. The goodness of the model fitness was checked via the Cox-Snell residual. A p-value less than 0.05 was used to declare the statistical significance of the variables.
resultsThe incidence density of diabetic neuropathy was 3.56 cases per 1,000 person months of observation, and the median time to develop diabetic neuropathy was 105 months. Advanced age (adjusted hazard ratio (AHR) 1.03 (95% CI: 1.01, 1.06)) and total cholesterol ≥ 200 mg/dl (AHR 2.52 (95% CI: 1.25, 5.09)) were statistically significant predictors of diabetic neuropathy.
conclusionAdvanced age and hypercholesterolemia were significantly associated predictors with diabetic neuropathy. Healthcare providers need to monitor cholesterol levels in order to prevent or delay diabetic neuropathy development in patients with type 2 diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.