Evidence map›Paper›PMID 41272711›Full record

ArticleBMC medicine2025

Combined impact of multiple healthy lifestyles on digestive diseases: a large population-based prospective cohort study.

Lei Yuan, Zixin Lan, Juanfang Zhu, Yan Chen, Yang Zhao, Nan Wang, Huimin Zheng, Zhengwei Wan, Lijuan Liu, Jinhai Sun and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lei Yuan *Department of Health Management, Faculty of Military Health Service, Naval Medical University, Shanghai, China.
Zixin Lan *Central Laboratory of the Medical Research Center, The First Affiliated Hospital of Ningbo University, Zhejiang Province, Ningbo, China.
Juanfang Zhu *Department of Health Management, Faculty of Military Health Service, Naval Medical University, Shanghai, China.
Yan ChenSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yang ZhaoSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Nan WangSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Huimin ZhengCentral Laboratory of the Medical Research Center, The First Affiliated Hospital of Ningbo University, Zhejiang Province, Ningbo, China.
Zhengwei WanDepartment of Health Management &, Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Lijuan LiuDepartment of Health Management, Faculty of Military Health Service, Naval Medical University, Shanghai, China.
Jinhai SunDepartment of Health Management, Faculty of Military Health Service, Naval Medical University, Shanghai, China.
Emad M El-OmarUNSW Microbiome Research Centre, St George and Sutherland Clinical Campuses, UNSW Sydney, Sydney, Australia. e.el-omar@unsw.edu.au.
Zhe ZhaoDepartment of Health Management, Faculty of Military Health Service, Naval Medical University, Shanghai, China. heavanzz@qq.com.
Pan LiCentral Laboratory of the Medical Research Center, The First Affiliated Hospital of Ningbo University, Zhejiang Province, Ningbo, China. danielfunny@126.com.

Funding

Joint TCM Science & Technology Projects of National Demonstration Zones for Comprehensive TCM Reform GZY-KJS-ZJ-2025-030National Natural Science Foundation of China 82201812National Natural Science Foundation of China 82401924Natural Science Foundation of Guangdong Province 2022A1515110278the Huadong Medicine Joint Fund of Zhejiang Provincial Natural Science Foundation of China LHDMZ25H040002The Talent Plan of Naval Medical University No. 2025-Yuan Lei
6 · The paper itself

Abstract

backgroundHealthy lifestyle modification is widely recommended for preventing digestive system diseases, but the effects of individual and combined behaviors, particularly potential interactions, are not fully understood.

methodsThis study investigates the association between six healthy lifestyle behaviors (moderate alcohol consumption, never smoking, adequate sleep, regular physical activity, a healthy diet, and limited sedentary behavior) and the risk of 20 digestive system diseases, participants were grouped into high, moderate, and low adherence. Cox proportional hazards models evaluated the associations between these behaviors and disease risk.

resultsAmong 267,408 participants, 53,690 (20.08%) were classified as high adherence group, 158,023 (59.09%) as moderate adherence group, and 55,695 (20.83%) as low adherence group. Compared with the low adherence group, the high adherence group had a hazard ratio of 0.72 (95% CI: 0.70 to 0.74) and the moderate adherence group 0.82 (95% CI: 0.80 to 0.84). Each behavior independently reduced risk, indicating there were only additive effects but no synergistic or antagonistic interactions.

conclusionsGreater adherence to healthy lifestyle behaviors is associated with a reduced risk of digestive system diseases. The absence of interactions among behaviors simplifies implementation, allowing individuals to focus on adopting as many behaviors as possible to maximize benefits.

Indexed as

Digestive System DiseasesHealthy LifestyleAdultAgedExerciseFemaleHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsSedentary BehaviorDigestive system diseasesGastrointestinal diseasesInteraction effectLifestyle behaviorsProspective cohort study

Identifiers

PMID41272711
PMCPMC12639982

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.