ArticlePediatric rheumatology online journal2025
Association of Mediterranean diet adherence with familial Mediterranean fever severity in a Lebanese cohort.
Article in Pediatric rheumatology online journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A Narrative Review on Integrative Bioinformatics Approaches for microRNA Research in Familial Mediterranean Fever: Current Insights and Future Directions.Health science reports · 2026Article
- Mediterranean diet adherence in pediatric familial Mediterranean fever: clinical and inflammatory correlates.Frontiers in pediatrics · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundFamilial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by a wide clinical variability among individuals, indicating that both genetic and environmental factors influence disease progression. Although the Mediterranean Diet (MD) is recognized for its anti-inflammatory properties, its relationship with FMF severity remains uninvestigated. This study aims to explore the association between MD adherence and FMF severity, while considering individuals' genetic background, lifestyle, and comorbid health conditions.
methodsA cross-sectional survey was conducted among 101 confirmed individuals with FMF in Lebanon. Data were collected using a questionnaire that included participants' demographics, socio-economic status, disease manifestations, comorbidities, treatment, and lifestyle habits. FMF severity was determined using the International Severity Score for FMF (ISSF), dietary adherence was assessed using the Modified Mediterranean Prime Screen (MMPS), and physical activity was evaluated using the International Physical Activity Questionnaire-Short Form (IPAQ-SF).
resultsAdherence to the MD Score (MDS) was categorized as low (34%), moderate (48%), and high (19%). Most MD component intakes did not meet the recommended ranges. While no relationship was found between MD adherence and FMF severity, specific clinical manifestations, such as diarrhea, differed significantly, with a higher frequency noted in the low MD group. Obesity, high levels of physical activity, and the presence of comorbidities-particularly rheumatoid manifestations, inflammatory bowel disease, and cardiovascular diseases-were associated with a significant increase in FMF severity among participants; however, none of these factors emerged as independent predictors in multivariate models.
conclusionsOur findings reinforce the multifactorial aspect of FMF and underscore the need for a comprehensive approach that addresses all contributing factors collectively.
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