Trial reportHead & face medicine2025
Effect of tricalcium silicate-based intracanal dressing on antibacterial-antifungal activity and postoperative pain intensity after non-surgical endodontic retreatment: randomized controlled clinical trial.
Trial report in Head & face medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06779370 (Evaluation of the Effect of Calcium Silicate-Based Root Canal Medicament on Antifungal-Antibacterial Activity and Post-Operative Pain After Retreatment), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effect of Calcium Silicate-Based Root Canal Medicament on Antifungal-Antibacterial Activity and Post-Operative Pain After Retreatment
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regenerative Potential of Biodentine in Complex Endodontic Conditions: A Systematic Review of Clinical and Radiological Evidence.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Comparative Evaluation of Bio-C Temp and Calcium Hydroxide as Intracanal Medicaments in Managing Postoperative Pain and Percussion Sensitivity in Symptomatic Irreversible Pulpitis: A Preliminary Prospective Observational Cohort Study.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectivesThis study aimed to evaluate the antibacterial and antifungal efficacy, as well as postoperative pain levels, following non-surgical retreatment of single-rooted teeth using tricalcium silicate- or calcium hydroxide-based intracanal dressings. MATERIALS AND
methodsForty-nine patients diagnosed with apical periodontitis were randomly assigned to two groups: tricalcium silicate (n = 25) and calcium hydroxide (n = 24). Microbiological samples were obtained before instrumentation (S1), after chemo-mechanical preparation (S2), and 10 days post-medication (S3). Total bacterial load and Candida albicans levels were quantified using qPCR. Postoperative pain was assessed on days 1, 3, 5, 7, and 10.
resultsNo significant differences were found between the groups in demographic variables. The calcium hydroxide group showed a significantly greater reduction in total bacterial load in S3 samples. No significant differences were observed between groups regarding C. albicans levels or postoperative pain at any time point. However, a significant reduction in pain was noted on day 1 compared to baseline in the calcium hydroxide group.
conclusionsBoth materials were effective in reducing microbial load; however, calcium hydroxide demonstrated superior antibacterial efficacy. Antifungal activity and postoperative pain outcomes were comparable between the groups.
trial registrationThis trial was registered at Clinicaltrials.gov on 15/01/2025 (NCT06779370).
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