ReviewJournal of nanobiotechnology2025
Recent advances in electric-stimulus assisted microneedle patches for skin disease treatment.
Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A hydrogel ionic circuit electrical stimulation system to restore denervated muscle following long-gap peripheral nerve injury.Bioactive materials · 2027Article
- Hydrogel microneedle delivery of a palmitoylated peptide promotes hair regeneration via dual activation of Wnt/β-catenin and cAMP-PKA signaling.Journal of nanobiotechnology · 2026Article
- Electronic Skins for Advanced Wound Healing: Biomimetic Thermoregulation and Bioelectrically Active Systems.Polymers · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Due to the natural barrier of skin structure, traditional topical drug utilization for skin disease management has been severely constrained by low bioavailability. While current microneedle (MN)-based systems confront challenges related to therapeutic efficacy, penetration depth, and delivery precision, they offer considerable promise as minimally invasive platforms. To address these limitations, electric stimulus (ES) has been strategically integrated as a programmable external trigger within microneedle patches, enabling spatiotemporal control over drug release kinetics. This review systematically delineates recent advancements in ES-assisted microneedle systems for managing dermatological conditions, highlighting their dual capacity to enhance transdermal permeability while minimizing systemic toxicity through localized delivery, in alignment with emerging trends in functional integration and device miniaturization. This encompasses a comprehensive analysis of the regulatory role of ES, strategic selection of power supply modules, and the rational design of microneedles in conjunction with their corresponding drug-loading strategies. Guided by the Three I Principles (Integrated-Intelligent-Individualized), future developments should focus on creating closed-loop systems with embedded biosensors for real-time biomarker monitoring, implementing AI-driven adaptive dosing algorithms, and developing modular microneedle arrays. This paradigm shift towards patient-centered care will require cross-disciplinary convergence of flexible electronics, biocompatible energy harvesters, and precision medicine approaches to accommodate personalized treatment regimens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.