Evidence map›Paper›PMID 41272565›Full record

ArticleBMC pregnancy and childbirth2025

GLIS3 rs7034200 and ADRB3 rs4994 genetic variants associated with an increased risk of gestational diabetes mellitus in Chinese women: a case-control study.

Liping Shui, Qingqing Liu, Xinghui Liu, Huai Bai, Yujie Wu, Yuting Sheng, Guolin He, Ping Fan

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Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Liping ShuiDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Qingqing LiuLaboratory of Genetic Disease and Perinatal Medicine, Laboratory of the Key Perinatal Disease, Key Laboratory of Birth Defects and Related Disease of Women and Children, West China Second University Hospital, Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
Xinghui LiuDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Huai BaiLaboratory of Genetic Disease and Perinatal Medicine, Laboratory of the Key Perinatal Disease, Key Laboratory of Birth Defects and Related Disease of Women and Children, West China Second University Hospital, Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
Yujie WuLaboratory of Genetic Disease and Perinatal Medicine, Laboratory of the Key Perinatal Disease, Key Laboratory of Birth Defects and Related Disease of Women and Children, West China Second University Hospital, Ministry of Education, Sichuan University, Chengdu, Sichuan, China.
Yuting ShengDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Guolin HeDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. heguolin19@163.com.
Ping FanLaboratory of Genetic Disease and Perinatal Medicine, Laboratory of the Key Perinatal Disease, Key Laboratory of Birth Defects and Related Disease of Women and Children, West China Second University Hospital, Ministry of Education, Sichuan University, Chengdu, Sichuan, China. fanping15@scu.edu.cn.

Funding

Key Research and Development Program of Sichuan Province 2019YFS0401National Key Research and Development Program of China 2016YFC1000400
6 · The paper itself

Abstract

backgroundGestational diabetes mellitus (GDM) has a complicated pathophysiology originating from interactions between susceptibility genes and adverse environmental factors. The transcription factor GLI-similar 3 (GLIS3) rs7034200C/A and adrenergic receptor beta 3 (ADRB3) rs4994T/C (Trp64Arg) polymorphisms are closely related to glucolipid metabolism, insulin resistance, obesity, and increased risk of type 2 diabetes. However, the association of these two polymorphisms with GDM in Chinese remains unknown. Therefore, this study explored the relationship between these two genetic variants and the risk of GDM, and assessed the effects of genotypes on glucolipid metabolism, oxidative stress, and clinical indicators.

methodsThis case-control study included 701 women with GDM and 1034 controls. The rs7034200C/A and rs4994T/C variants were genotyped using polymerase chain reaction-restriction fragment length polymorphism method. Clinical and biochemical parameters were analyzed.

resultsThe GLIS3 rs7034200C/A polymorphism was associated with an elevated risk of GDM according to the genotype, allele, dominant, and recessive genetic models (P < 0.05). After correcting for maternal age, pre-pregnancy BMI, and gestational age at sampling, the dominant and recessive models retained statistical significance in the binary logistic regression models (odds ratio [OR] = 1.268 and 1.334, 95% confidence interval [CI]: 1.017-1.580 and 1.020-1.745, respectively; P < 0.05) ; the AA genotype showed a higher risk for GDM, with the CC genotype as the reference, in a multinomial logistic regression model (OR = 1.519, 95% CI: 1.120-2.061; P = 0.007). No significant discrepancies were observed in the ADRB3 rs4994T/C polymorphism based on different genetic models (P > 0.05). However, the AA/TT combined genotype of the GLIS3 rs7034200C/A and ADRB3 rs4994T/C polymorphisms was associated with an elevated risk of GDM, with the CC/TT combined genotype as a reference (OR = 1.708, 95% CI: 1.191-2.450; P = 0.004). Furthermore, the GLIS3 rs7034200C/A variant significantly affected oxidative stress, insulin resistance, and glucolipid metabolism.

conclusionsThe A allele and AA genotype of the GLIS3 rs7034200C/A polymorphism, along with the AA/TT combined genotype of the GLIS3 rs7034200C/A and ADRB3 rs4994T/C variants, are genetic risk factors for GDM in Chinese women.

Indexed as

Diabetes, GestationalReceptors, Adrenergic, beta-3Transcription FactorsAdultAllelesCase-Control StudiesChinaDNA-Binding ProteinsEast Asian PeopleFemaleGenetic Predisposition to DiseaseGenotypeHumansOxidative StressPolymorphism, Single NucleotidePregnancyADRB3 protein, humanDNA-Binding ProteinsGLIS3 protein, humanReceptors, Adrenergic, beta-3Repressor ProteinsTrans-ActivatorsTranscription FactorsADRB3Genetic polymorphismGestational diabetes mellitusGLIS3Glucolipid metabolismOxidative stress

Identifiers

PMID41272565
PMCPMC12639765

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.