Evidence map›Paper›PMID 41272555›Full record

ReviewBMC cardiovascular disorders2025

Cardiomyocyte maturation and proliferation is a flip coin.

Riham R E Abouleisa, Kamal Abou Farraj, Stuti G Mehta, Tamer M A Mohamed

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Riham R E AbouleisaDepartment of Surgery, Baylor College of Medicine, 6770 Bertner Avenue, Houston, TX, 77030, USA. Riham.abouleisa@bcm.edu.ORCID 0000-0001-8883-068X
Kamal Abou FarrajDepartment of Surgery, Baylor College of Medicine, 6770 Bertner Avenue, Houston, TX, 77030, USA.
Stuti G MehtaCollege of Natural Sciences, University of Texas at Austin, Austin, TX, 7872, USA.
Tamer M A MohamedDepartment of Surgery, Baylor College of Medicine, 6770 Bertner Avenue, Houston, TX, 77030, USA.

Funding

Induction of Cardiomyocyte Proliferation via Transient Expression of Cell Cycle Factors as a Promising Therapy for Heart FailureR01HL147921 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Tamer M A Mohamed, Jonathan Satin · 2020 to 2026
$5.3M
Defining the major signaling mechanism which controls spontaneous cardiomyocyte proliferation in the Neonatal StageR01HL178610 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Tamer M A Mohamed · 2025 to 2026
$1.5M
Triple Gene Therapy for Ischemic Heart FailureR61HL177472 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MOHAMED, TAMER M A, ROSENGART, TODD K · 2025 to 2025
$560k
NHLBI NIH HHS R01 HL147921NHLBI NIH HHS R01 HL178610NHLBI NIH HHS R61 HL177472NIH HHS NIH 2R01 HL1479
6 · The paper itself

Abstract

Cardiac regeneration offers a promising approach to treating ischemic heart disease. Accumulating evidence indicates that maturation limits the proliferative capacity of the adult myocardium. During cardiac development, cardiomyocytes (CMs) undergo genetic reprogramming, leading to maturation characterized by polyploid CMs, increased sarcomere rigidity, and metabolic reprogramming that prepares the heart for efficient, sustained blood pumping capacity throughout life. This maturation process also coincides with cell cycle exit in adult CMs and forms a barrier to replenishing the CM loss after ischemic injury. Over recent decades, studies have shown that forced induction of adult CM proliferation involves reversion to an immature state. Therefore, understanding the changes that occur during maturation is essential to flip the coin to enable the induction of CM proliferation in adulthood, with potential therapeutic applications for ischemic heart disease. This review discusses the relationship between postnatal CM maturation and CM proliferation.

Indexed as

Cell DifferentiationCell ProliferationMyocytes, CardiacRegenerationAnimalsCellular ReprogrammingHumansSignal TransductionCardiac regenerationCardiomyocyte postnatal maturationCardiomyocyte structureCell cycle exitMetabolism

Identifiers

PMID41272555
PMCPMC12752010

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.