ArticleBMC infectious diseases2025
Global burden of Klebsiella pneumoniae infections and antimicrobial resistance in 2019.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Antibiotic Resistance and the Return to a Pre-Antibiotic Era: A Critical Narrative Review of a Global Catastrophe.Biomedicines · 2026Review
- Receptor Structure Shapes Host Range but Incompletely Predicts High Activity inAntibiotics (Basel, Switzerland) · 2026Article
- Antimicrobial resistance analysis of Klebsiella pneumoniae bloodstream infections based on a random forest algorithm: a longitudinal study based on data from tertiary hospitals in China from 2012 to 2023.International health · 2026Article
- Carbapenem-ResistantMicroorganisms · 2026Review
- Global Trends in Antimicrobial Resistance-Related Mortality fromTropical medicine and infectious disease · 2026Article
- Interconnected Reservoirs: Virulence & Biofilm Traits of ESBL-Microorganisms · 2026Article
- Global, regional, and national burden of pathogen-attributable infectious diseases in children by age and sex, 1990-2021: a systematic analysis.Infection · 2026Article
- Prevalence, antimicrobial resistance, and associated factors of critical superbugs Klebsiella pneumoniae and Acinetobacter species among hospitalized patients in Northwest Ethiopia.BMC microbiology · 2026Article
- Current State of the Fight Against Antimicrobial Resistance: What Are the Different Strategies for Tomorrow?Antibiotics (Basel, Switzerland) · 2026Review
- The Role of Neonatal Ward Environment as a Reservoir for the Dissemination of Multidrug-Resistant Klebsiella pneumoniae in Algeria.MicrobiologyOpen · 2026Article
- Klebsiella pneumoniae in the global AMR: resistance mechanisms and genomic adaptation.World journal of microbiology & biotechnology · 2026Review
- WGS-based in silico analysis of clinically-associated Klebsiella pneumoniae genomes: insights into antimicrobial resistance, virulence determinants, and plasmid dynamics.Molecular genetics and genomics : MGG · 2026Article
- Molecular Insights into Carbapenem Resistance inInternational journal of molecular sciences · 2026Review
- Antibiotic resistance inFrontiers in microbiology · 2026Review
- Machine learning-assisted prognostic model for mortality in ICU patients with culture-confirmedFrontiers in cellular and infection microbiology · 2026Article
- Phage therapy againstFrontiers in microbiology · 2026Review
- Refractory XDRLe infezioni in medicina · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeTo conduct an extensive analysis of the global burden of Klebsiella pneumoniae (K. pneumoniae) infections and antimicrobial resistance (AMR) using data from 2019, encompassing international, regional, and national perspectives.
methodsThe methodology employed in this study involved collecting data on K. pneumoniae infections and AMR from two reputable sources: the Global Burden of Disease Study (GBD) 2019 and the Global Burden of Antimicrobial Resistance 2019 study. The analysis was based on a vast compilation of 471 million records, which informed eight distinct modeling components.
resultsK. pneumoniae infections have resulted in approximately 800,000 deaths worldwide, with 80% associated with AMR. Notably, lower respiratory tract infections, bloodstream infections, and intra-abdominal infections were identified as the primary infections caused by K. pneumoniae, accounting for nearly 90% of K. pneumoniae-related deaths and exhibiting the highest age-standardized mortality rates. South Asia and sub-Saharan Africa showed the greatest incidence of fatalities linked to K. pneumoniae infections, with the latter region additionally displaying the highest number and rate of deaths associated with antimicrobial-resistant Klebsiella pneumoniae (KP-AMR). The mortality attributed to KP-AMR was predominantly caused by resistance to carbapenems and third-generation cephalosporins, accounting for more than 50% of the reported deaths.
conclusionsK. pneumoniae infections and antimicrobial resistance significantly impact sub-Saharan Africa and South Asia, underscoring an urgent need for targeted interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.