Evidence map›Paper›PMID 41272540›Full record

ArticleBMC public health2025

Unmasking pandemic patterns: decoding the COVID-19's impact on mortality in Italy with Generalized Gamma overdispersion model.

Danila Azzolina, Rosanna Comoretto, Daniela Ferrante, Corrado Magnani, Dario Gregori

Abstract read
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Danila AzzolinaDepartment of Translational Medical Science, Biostatistics and Clinical Trial Methodology Unit, Clinical Research Center DEMeTra, University of Naples Federico II, Naples, Italy.
Rosanna ComorettoDepartment of Pediatrics and Public Health, University of Turin, Turin, Italy.
Daniela FerranteDepartment of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
Corrado MagnaniDepartment of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
Dario GregoriDepartment of Cardiac Thoracic, Vascular Sciences, Unit of Biostatistics, Epidemiology and Public Health, University of Padua, Via Loredan 18, Padua, 35131, Italy. dario.gregori@unipd.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundItaly has been significantly impacted by the COVID-19 pandemic, particularly in its early stages, resulting in healthcare strain, societal restrictions, and disruption. Understanding the long-term effects, notably excess mortality beyond the initial peaks, remains important. Prior studies have focused on the early phase, leaving out subsequent and updated mortality trends.

methodThis study analyzes Italian mortality rates from 2015 to 2023, employing Generalized Additive Models for Location, Scale, and Shape (GAMLSS), the Generalized Gamma Overdispersion model. Data analysis considered factors such as gender, age groups (under 65 and 65 or older), and geographical differences (Northern versus Central-Southern Italy) as key characteristics of the mortality trend.

resultsThe study identified several phases of the pandemic, characterized by a significant early 2020 mortality peak and subsequent smaller peaks. Mortality rates were higher in Northern Italy, with males and the elderly being the most affected. Overall, mortality rates increased during the pandemic, particularly among these groups, and then returned to normal levels in 2023. An increase in the overdispersion parameter, estimated via the GAMLSS model, is evident in the post-pandemic phase and persists until 2023.

conclusionThe findings highlight the complex nature of COVID-19's impact on mortality in Italy. They reveal the temporal phases, regional disparities, and demographic vulnerabilities that contribute to the overall mortality picture. The overdispersion component indicates more significant variability and unpredictability of mortality patterns until 2023. This highlights the intricate interplay of factors, including healthcare capacity, viral mutations, and the effectiveness of public health responses. This study emphasizes the need for targeted interventions and protective measures in the most affected groups.

Indexed as

COVID-19MortalityPandemicsAdolescentAdultAgedAged, 80 and overFemaleHumansItalyMaleMiddle AgedModels, StatisticalSARS-CoV-2Young AdultCOVID-19Excess mortalityGeneralized gamma modelItaly

Identifiers

PMID41272540
PMCPMC12754894

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.