Evidence map›Paper›PMID 41272531›Full record

ArticleBMC infectious diseases2025

Prevalence and determinants of chronic kidney disease among HIV/AIDS patients in selected governmental hospitals at Addis Ababa, Ethiopia: a retrospective cross-sectional study.

Getasew Kassaw Alemu, Nebiyu Getachew, Selam Bogale Gissa, Zemichael Getu Alemayehu, Mikiyas Gifawosen Teferi, Fitsum Assefa Gemechu, Abebe Worku Teshager, Anteneh Eshetu Berga, Bewuketu Terefe, Addisu Melkie Ejigu

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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5 · Who and what money

Authors and funding

10 authors.

Getasew Kassaw AlemuNephrology Unit, Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. gechkassaw251980@gmail.com.ORCID http://orcid.org/0000-0001-8592-7099
Nebiyu GetachewInfectious Disease Unit and Yekatit - 12 Hospital Medical College, Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Selam Bogale GissaNephrology Unit, Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Zemichael Getu AlemayehuCollege of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Mikiyas Gifawosen TeferiCollege of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Fitsum Assefa GemechuCollege of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Abebe Worku TeshagerDepartment of Internal Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Anteneh Eshetu BergaInfectious Disease Unit, Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Bewuketu TerefeCommunity Health Nursing Department, School of Nursing, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Addisu Melkie EjiguNephrology Unit, Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe burden of noncommunicable diseases, particularly kidney dysfunction, is increasingly common among HIV/AIDS patients, especially with the improved life expectancy resulting from the advent of antiretroviral therapy. However, there are limited data on the prevalence and determinants of chronic kidney disease in this population. Therefore, this study aimed to assess the prevalence and determinants of chronic kidney disease among HIV/AIDS patients at two government hospitals in Ethiopia in 2024.

methodsA retrospective cross-sectional study was conducted among 422 adult HIV/AIDS patients, selected via systematic random sampling techniques with a sampling frame, at two governmental hospitals at Addis Ababa, Ethiopia. The data were collected via the kobo tool box software, and the analysis was performed via Stata software version 17. Variables with a p-value of ≤ 0.2 in the bivariate analysis were included in the multivariable logistic regression model, and variables with a p-value of less than 0.05 in the final model were considered statistically significant.

resultsAmong the 422 participants, 54 (12.8%) were excluded for having inadequate kidney function determination and 368 participants were included in the final analysis. The prevalence of chronic kidney disease in this study was 59 (16.03%). Those individuals with higher education (AOR = 0.53, 95% CI: 0.39-0.93) and self-employed status (AOR = 0.83, 95% CI: 0.33-0.98) were less likely to have chronic kidney disease. Age > 64 years was (AOR = 2.99, 95% CI: 1.05-8.57), antiretroviral therapy duration > 20 years was (AOR = 5.84, 95% CI: 3.77-14.53), being widowed was (AOR = 1.32, 95% CI: 1.04-3.88), and diarrheal disease in the study period of (AOR = 1.27, 95% CI: 1.06-3.27) times was significantly associated with the occurrence of chronic kidney disease.

conclusionsThe prevalence of chronic kidney disease in this study was relatively high compared to national and regional estimates. Significant factors associated with chronic kidney disease included older age, longer duration on antiretroviral therapy, history of diarrheal disease, being widowed, higher educational status, and self-employment. These findings highlight the need for the integration of routine kidney function screening into HIV care services to support early detection and management of chronic kidney disease in this population. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

HIV InfectionsRenal Insufficiency, ChronicAdolescentAdultAgedCross-Sectional StudiesEthiopiaFemaleHospitals, PublicHumansMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsYoung AdultChronic kidney disease and HIVEthiopiaHIV/AIDSKidney dysfunction and HIV

Identifiers

PMID41272531
PMCPMC12750920

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.