ArticleBMC medical imaging2025
Improved stroke risk stratification in carotid atherosclerosis: integrating intraplaque neovascularization into Carotid Plaque-RADS.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Dynamic Contrast-Enhanced Ultrasound for Carotid Plaque Characterization: An Algorithm-Aware Technical Review.Diagnostics (Basel, Switzerland) · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study evaluates whether IPN, as assessed by contrast-enhanced ultrasound (CEUS), enhances stroke risk stratification within the Carotid Plaque-RADS framework.
methodsWe conducted a retrospective analysis of 157 stroke patients between July 2020 and January 2021. IPN grade was assessed using CEUS, and patients were categorized based on the Carotid Plaque-RADS. The recurrence-free survival (RFS) rates were calculated, and the incremental value of incorporating IPN grades into Carotid Plaque-RADS was analyzed.
resultsDuring a follow-up period of 35 ± 10 months, 44 out of the 157 stroke patients experienced recurrent strokes. There was significant difference in the incidences of stroke recurrence between IPN Grade 1 and Grade 2 (12.6% vs. 57.4%, p < 0.001). Integration of IPN grading with Carotid Plaque-RADS resulted in disparities in RFS rates between RADS 2 and RADS 3, as well as between RADS 3 and RADS 4 (both P < 0.05), which did not exist in the Carotid Plaque-RADS score alone. Furthermore, significant difference in RFS rates were noted between Carotid Plaque-RADS ≤ 3 patients with IPN Grade 2 and those with IPN Grade 1 (P < 0.001). Among patients initially categorized under Carotid Plaque-RADS ≤ 3, 7.7% (8/104) were accurately reclassified, demonstrating a net reclassification improvement of 12.0% after incorporating IPN grades into the Carotid Plaque-RADS. Additionally, the incorporation of IPN grades with Carotid Plaque-RADS led to a substantial increase in the chi-square value (chi-square difference = 20.62; likelihood ratio test P < 0.001).
conclusionIntegration of the presence of IPN Grade 2 into Carotid Plaque-RADS significantly enhanced its ability for stratifying stroke recurrence risk.
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