ArticleBMC public health2025
Global trends (1990-2021) and trojections to 2050 in alcohol-attributable epilepsy burden among adults over 40 years old.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundEpilepsy in Middle-aged and older adults has become a growing global health burden, with long-term alcohol consumption emerging as one of the key modifiable risk factors.
methodsLeveraging comprehensive data from the Global Burden of Disease (GBD) 2021 study, we systematically evaluated mortality and morbidity metrics - including deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), years of life lost (YLLs), and corresponding age-standardized rates (ASRs) - across 204 countries and territories. Temporal trends from 1990 to 2021 were quantified using estimated annual percentage changes (EAPCs). For burden projections through 2050, we employed three complementary modeling approaches: Bayesian age-period-cohort (BAPC) analysis, autoregressive integrated moving average (ARIMA) modeling, and Exponential Smoothing (ES) techniques. Furthermore, we conducted decomposition analyses to differentiate the impacts of demographic shifts, population aging, and epidemiological transitions, complemented by comprehensive inequality assessments.
resultsGlobally in 2021, alcohol-related epilepsy accounted for 3,003 deaths (95% uncertainty interval [UI]: 2,116-3,933) and 241,378 disability-adjusted life years (DALYs; 95% UI: 157,104-345,001) among adults aged ≥ 40 years. The disease burden demonstrated significant gender disparities, with males bearing 2.1-fold higher age-standardized DALY rates (17.09 per 100,000 population) compared to females. Geographic analysis revealed distinct patterns: middle Socio-demographic Index (SDI) quintiles showed the highest absolute case numbers, while age-standardized rates exhibited a characteristic U-shaped distribution across the SDI spectrum. Temporal trends from 1990 to 2021 showed a 67.4% increase in mortality and 64.7% rise in DALYs, contrasting with a 14.5% decline in age-standardized rates (from 19.99 to 17.09 per 100,000).
conclusionAlcohol-related epilepsy represents a growing and substantial public health burden among aging populations worldwide, demonstrating pronounced disparities by gender, age, and geographic region. Our findings highlight the critical need for a dual intervention approach: implementing targeted alcohol control measures while developing tailored regional strategies to address demographic shifts and epidemiological risks. These results provide compelling evidence for prioritizing alcohol regulation within public health initiatives for aging societies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.