Evidence map›Paper›PMID 41272452›Full record

ArticleBMC plant biology2025

Enhanced salinity stress tolerance and growth promotion in Melissa officinalis using caffeic acid nanocomposites as a promising nano-bio-based strategy.

Leila Ranjbar, Seyed Mehdi Razavi, Ahlam Khalofah, Abazar Ghorbani

Abstract read
In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leila RanjbarDepartment of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, 13131561991, Iran.
Seyed Mehdi RazaviDepartment of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, 13131561991, Iran. razavi694@gmail.com.
Ahlam KhalofahBiology Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia.
Abazar GhorbaniNational Key Laboratory for the Development and Utilization of Forest Food Resources, State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of State Forestry and Grassland Administration on Subtropical Forest Biodiversity Conservation, College of Life Sciences, The Southern Modern Forestry Collaborative Innovation Center, Nanjing Forestry University, Nanjing, 210037, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of caffeic acid (CA) and its nano-composite form (CA-NCs) has great promise for improving growth and abiotic stress tolerance because of the nano-composite formulation’s higher stability, bioavailability, and targeting. Limited research exists on caffeic acid nanocomposites in salinity-sensitive M. officinalis, with unexplored comparative efficacy against free caffeic acid in regulating photosynthesis, osmotic adjustment, and antioxidant activity. Thus, we assessed the potential of CA-NCs on growth and stress tolerance in Melissa officinalis grown during salinity compared to the free form of CA. The CA-NCs were synthesized and characterized through FTIR, TGA, and SEM analyses. CA-NCs demonstrated superior efficacy over free CA in mitigating NaCl stress in plants. Characterization confirmed their small size (99.8 nm), enhancing stability and bioavailability. Under salt stress, CA-NCs significantly improved root and shoot biomass, photosynthetic efficiency, and chlorophyll content. They effectively modulated osmotic stress by regulating relative water content and proline, while strongly reducing oxidative damage markers (MDA, H₂O₂). CA-NCs also boosted the activity of antioxidant enzymes and promoted the synthesis of protective secondary metabolites like flavonoids and anthocyanins. These synergistic effects highlight CA-NCs as a highly promising agricultural tool for enhancing plant growth and abiotic stress tolerance.

Indexed as

Caffeic AcidsMelissaNanocompositesSalt ToleranceAntioxidantsPhotosynthesisSalt StressAntioxidantscaffeic acidCaffeic AcidsAntioxidant systemCaffeic acid nanocompositesMelissa officinalisOsmotic stressSalinity stressSecondary metabolites

Identifiers

PMID41272452
PMCPMC12639746

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.