Evidence map›Paper›PMID 41272319›Full record

ArticleNature chemical biology2026

Dynamic metal coordination controls chemoselectivity in a radical halogenase.

Elijah N Kissman, Ioannis Kipouros, Jeffrey W Slater, Elizabeth A Stone, Avery Y Yang, Augustin Braun, Alder R Ensberg, Andrew M Whitten, Kuntal Chatterjee, Isabel Bogacz and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Emerging classes of copper enzymes.Current opinion in chemical biology · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Elijah N KissmanDepartment of Chemistry, University of California, Berkeley, CA, USA.ORCID 0000-0002-3278-8010
Ioannis KipourosDepartment of Chemistry, University of California, Berkeley, CA, USA.
Jeffrey W SlaterDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-1126-8905
Elizabeth A StoneDepartment of Chemistry, University of California, Berkeley, CA, USA.ORCID 0000-0002-2253-3452
Avery Y YangDepartment of Chemistry, University of California, Berkeley, CA, USA.
Augustin BraunDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9487-5769
Alder R EnsbergDepartment of Chemical & Biomolecular Engineering, University of California, Berkeley, CA, USA.
Andrew M WhittenDepartment of Chemistry, University of California, Berkeley, CA, USA.ORCID 0000-0002-7968-6433
Kuntal ChatterjeeMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Isabel BogaczMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Junko YanoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0001-6308-9071
J Martin BollingerDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0003-0751-8585
Michelle C Y ChangDepartment of Chemistry, University of California, Berkeley, CA, USA. mcchang@princeton.edu.ORCID 0000-0003-3747-7630

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Biological Spectroscopy and Crystallography Using an X-ray Free Electron Laser - Supplemental EquipmentR01GM110501 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Junko Yano · 2014 to 2026
$4.8M
Discovery and Application of New HalogenasesR01GM134271 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2020 to 2023
$1.5M
Structures and Mechanisms of “Heme-oxygenase-like” Non-heme Di-iron Enzymes that Catalyze Complex N-oxygenation and Olefin-installing C–C-Fragmentation ReactionsR01GM138580 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOLLINGER, JOSEPH M · 2020 to 2023
$1.3M
Interrogating the Haloferryl State of Iron(II)- and 2-Oxoglutarate-Dependent Halogenases through Mimicry and Active Site ModificationsF32GM136156 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SLATER, JEFFREY WORTHINGTON · 2020 to 2022
$201k
NIGMS NIH HHS F32 GM136156NIGMS NIH HHS R01 GM110501NIGMS NIH HHS R01 GM134271NIGMS NIH HHS R01 GM138580NIGMS NIH HHS T32 GM066698U.S. Department of Energy (DOE) DEAC02-05CH11231 FWP CH030201
6 · The paper itself

Abstract

The activation of inert C(sp

Indexed as

IronOxidoreductasesBiocatalysisCrystallography, X-RayHydrogen BondingKetoglutaric AcidsModels, MolecularIronKetoglutaric AcidsOxidoreductases

Identifiers

PMID41272319
PMCPMC13077581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.