SynthesisEvidence-based dentistry2025
Effectiveness of mouth rinses on caries prevention and arrest: an umbrella review.
Synthesis in Evidence-based dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAmong various fluoride delivery methods, such as toothpaste, varnishes, and water fluoridation, mouthrinses have gained attention for their versatility, ease of use, and potential to complement other preventive strategies. The aim was to evaluate the effectiveness of mouthrinses in preventing and arresting caries by synthesizing data from existing systematic reviews.
methodsFive electronic databases, named PubMed, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Web of Science and Scopus, were searched to identify systematic reviews that assessed the effect of mouthrinses containing chemical, herbal, or natural agents in comparison to standard oral care, placebo, water, or saline in the development or arrest of crown or root caries. Eligible reviews were selected, and data were extracted and assessed for bias.
resultsThree systematic reviews with meta-analysis and four without were included, with a total of eighty-three initial studies (moderate overlap). Supervised regular use of fluoride mouthrinse can reduce coronal and root caries initiation and progression in permanent teeth for an observational period of 6 months to 4 years. The only significant effect was in favor of the fluoride mouthrinse for crown caries at 36 months and root caries at 48 months follow-up time.
conclusionsMouthrinses effectively reduce the occurrence of crown caries in moderate- and high-risk patients, as well as root caries in older adults. However, their anticaries benefit in populations with additional fluoride exposure remains uncertain. CLINICAL SIGNIFICANCE: Given the great variability in the design, inclusion criteria set and conduct of the eligible systematic reviews, it is impossible to reach specific conclusions concerning the efficacy of any single product. However, it seems that fluoride mouthrinses are effective in preventing and/or arresting dental caries in moderate and high caries risk patients and may reduce initiation of root caries in older individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.