Evidence map›Paper›PMID 41272307›Full record

ArticleThe Journal of antibiotics2026

Thiofrenomycins, new kalafungin-type pyranonaphthoquinone skeleton with sulfide linkage from Streptomyces sp. MM863L-181F9.

Tomoyuki Kimura, Yoshimasa Ishizaki, Maya Umekita, Rie Arisaka, Hideyuki Muramatsu, Chigusa Hayashi, Isao Momose, Ken Shimuta, Ryuichi Sawa, Masayuki Igarashi

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tomoyuki KimuraInstitute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0864-4954
Yoshimasa IshizakiInstitute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0001-6893-0050
Maya UmekitaInstitute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, Japan.
Rie ArisakaInstitute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, Japan.
Hideyuki MuramatsuInstitute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5900-2113
Chigusa HayashiInstitute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, Japan.
Isao MomoseInstitute of Microbial Chemistry (BIKAKEN), Numazu, 18-24 Miyamoto, Numazu-shi, Shizuoka, Japan.ORCID http://orcid.org/0000-0002-9867-3881
Ken ShimutaDepartment of Latent Infection, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Ryuichi SawaInstitute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, Japan. rsawa@bikaken.or.jp.ORCID http://orcid.org/0000-0002-8190-0195
Masayuki IgarashiInstitute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, Japan. igarashim@bikaken.or.jp.ORCID http://orcid.org/0000-0002-1562-6685

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neisseria gonorrhoeae is the bacterium that causes gonorrhea, and multidrug resistance is becoming progressively more severe in many countries. Therefore, limited drugs are available for treatment. It is predicted that further drug resistance will be acquired, making treatment still more difficult, so there is an urgent need to develop new drugs. We discovered three compounds with a new kalafungin-type pyranonaphthoquinone skeleton, thiofrenomycins A-C, that exhibit strong antibacterial activity against N. gonorrhoeae in a culture solution of Streptomyces sp. MM863L-181F9 derived from fallen leaves. The absolute stereochemistry of these compounds was determined using X-ray crystal structure analysis. These substances exhibit minimal inhibitory concentrations of 0.125-16 µg/mL against N. gonorrhoeae.

Indexed as

Anti-Bacterial AgentsNaphthoquinonesStreptomycesSulfidesCrystallography, X-RayMicrobial Sensitivity TestsMolecular StructurePlant LeavesAnti-Bacterial AgentsNaphthoquinonesSulfides

Identifiers

PMID41272307

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.