Evidence map›Paper›PMID 41272286›Full record

ArticleJournal of racial and ethnic health disparities2025

Factors Associated with Medication Adherence and Glycemic Control among American Indian/Alaska Native Adults with Type 2 Diabetes Within a Commercial Health Care System: A System-Wide Cross-Sectional Study.

Leandra Bitterfeld, Angela G Brega, Jennifer Dailey-Vail, Figaro Loresto, Jason West, Christine T Rael

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Article in Journal of racial and ethnic health disparities, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Leandra BitterfeldUniversity of Colorado College of Nursing, Aurora, CO, USA. leandra.bitterfeld@imail.org.ORCID http://orcid.org/0000-0002-6823-2065
Angela G BregaCenters for American Indian & Alaska Native Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-7319-4892
Jennifer Dailey-VailUniversity of Colorado College of Nursing, Aurora, CO, USA.ORCID http://orcid.org/0009-0000-0596-0420
Figaro LorestoUniversity of Colorado College of Nursing, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-5967-7372
Jason WestIntermountain Health, Denver, CO, USA.
Christine T RaelUniversity of Colorado College of Nursing, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-6303-3809

Funding

DAISY Foundation HEG-2024-1132University of Colorado School of Medicine, Anschutz Medical Campus University of Colorado School of Medicine, Anschutz Medical Campus
6 · The paper itself

Abstract

introductionAmerican Indian and Alaska Native (AI/AN) adults experience type 2 diabetes (T2DM) at twice the rate of non-Hispanic White adults in the United States. Despite the importance of medication adherence for T2DM management, research in this area among AI/ANs is sparse, especially within the context of a commercial health care system. We sought to identify factors associated with medication adherence among AI/AN adults with T2DM and examined the relationship of adherence with glycemic control (hemoglobin A1C).

methodsThis cross-sectional study was conducted with patients from a commercial healthcare system. Data stemmed from online surveys completed by participants, paired with data from participants' electronic health records (EHRs). The World Health Organization Multidimensional Adherence Model was used to select potentially significant predictors of adherence (social determinants of health, patient-provider relationship, diabetes-related comorbidities, medication regimen complexity, outcome expectancies and self-efficacy). Linear regression and a mediator model were used.

resultsThe sample included n = 88 participants with an average A1C = 7.7. The multiple regression model revealed only age and self-efficacy as significant predictors of medication adherence, explaining 27% of its variability. Medication adherence explained 25% of the variability in A1C. In the mediator model, medication adherence fully mediated the relationship between self-efficacy and A1C.

conclusionAmong the many factors potentially related to medication adherence, self-efficacy was the only modifiable factor significantly associated with adherence. System- and individual-level interventions that target enhanced self-efficacy may have a meaningful impact on improved medication adherence and glycemic control.

Indexed as

Alaska NativeAmerican IndianGlycemic controlMedication adherenceType 2 diabetes

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.