Evidence map›Paper›PMID 41272274›Full record

ArticleScientific reports2025

Targeting the proteasome subunit PSMB5 by RNA interference induces proteasome dysfunction and mortality in the Colorado potato beetle (Leptinotarsa decemlineata).

Leonie Graser, Eric Rl Gordon, Matthew Jamison, Win Talton, Yuting Chen, Eileen Knorr, Anton Windfelder, Kenneth Narva, Andreas Vilcinskas

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Design of Lipopeptides and dsRNA-Lipopeptide Complexes for Sprayable RNAi-Based Plant Protection.Journal of peptide science : an official publication of the European Peptide Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leonie GraserInstitute for Insect Biotechnology, Justus Liebig University, 35390, Giessen, Germany. leonie.graser@uni-giessen.de.
Eric Rl GordonGreenLight Biosciences, Research Triangle Park, NC, 27709, USA.
Matthew JamisonGreenLight Biosciences, Research Triangle Park, NC, 27709, USA.
Win TaltonGreenLight Biosciences, Research Triangle Park, NC, 27709, USA.
Yuting ChenGreenLight Biosciences, Research Triangle Park, NC, 27709, USA.
Eileen KnorrBranch Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, 35392, Giessen, Germany.
Anton WindfelderBranch Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, 35392, Giessen, Germany.
Kenneth NarvaGreenLight Biosciences, Research Triangle Park, NC, 27709, USA.
Andreas VilcinskasInstitute for Insect Biotechnology, Justus Liebig University, 35390, Giessen, Germany. andreas.vilcinskas@ime.fraunhofer.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Colorado potato beetle (CPB, Leptinotarsa decemlineata) is a devastating super-pest of potato crops in the northern hemisphere. Chemical control methods are expensive, harmful to non-target species, and inefficient because CPB populations can rapidly evolve resistance to multiple classes of insecticides. Double-stranded RNA (dsRNA) provides an opportunity for the sustainable and targeted control of CPB by RNA interference (RNAi). A dsRNA active ingredient (ledprona, marketed as Calantha

Indexed as

ColeopteraInsect ProteinsProteasome Endopeptidase ComplexRNA InterferenceAnimalsLarvaRNA, Double-StrandedSolanum tuberosumInsect ProteinsProteasome Endopeptidase ComplexRNA, Double-StrandedFunctional genomicsPest controlProteomicsRNA interferenceUbiquitin

Identifiers

PMID41272274
PMCPMC12639069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.