ArticleScientific reports2025
A novel method of quantifying retinal vascular tortuosity in retinopathy of prematurity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study evaluated the diagnostic performance of a novel vessel tracing software that quantifies retinal vessel tortuosity in premature infants for assessing retinopathy of prematurity (ROP). Seventy-three retinal images of premature infants were subjectively classified as having "Normal" or "Abnormal" tortuosity based on arterial tortuosity of the posterior retina by seven clinicians. The software then semi-automatically traced the same arteries within circular regions of interest centered at the optic disc, with radii ranging from 2 to 20x the disc diameters. Vessel tortuosity was defined as the sum of external angles at vessel bend points. Tortuosity was significantly greater in Abnormal images within regions exceeding 4-disc diameters (p < 0.05). Diagnostic accuracy improved with larger regions: the area under the curve increased from 0.56 at 2 times to 0.90 at 8 times and 1.00 at 14 times the diameter. At 14 times, corresponding approximately to Zone I, the software achieved 100% sensitivity and specificity for detecting abnormal tortuosity. The software accurately quantified vessel tortuosity especially within Zone I of the retina, which may reduce inter-observer variability and aid clinicians, including non-specialists, in the evaluation of ROP eyes.
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