Evidence map›Paper›PMID 41272208›Full record

ArticleScientific reports2025

Spatial lipidomics reveals altered lipid profiles in TMEM63A mutant rats with hypomyelination.

Junyu Wang, Liang Wang, Yu Zhang, Kai Gao, Jiangxi Xiao, Lin Nie, Jihang Luo, Shiqi Yang, Ye Wu, Yuwu Jiang and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junyu WangChildren's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China.
Liang WangGuidon (Beijing) Pharmaceutics LTD, Beijing, 100176, China.
Yu ZhangChildren's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China.
Kai GaoChildren's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China.
Jiangxi XiaoDepartment of Radiology, Peking University First Hospital, Beijing, 100034, China.
Lin NieLaboratory of Electron Microscopy, Ultrastructural Pathology Center, Peking University First Hospital, Beijing, 100034, China.
Jihang LuoChildren's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China.
Shiqi YangChildren's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China.
Ye WuChildren's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China.
Yuwu JiangChildren's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China.
Huifang Yan *Children's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China. yanhuifang96@163.com.
Jingmin Wang *Children's Medical Center, Peking University First Hospital, No.5 Le Yuan Road, Daxing District, Beijing, 102627, China. wang66jm@163.com.

Funding

National Key Research and Development Program of China 2022YFC2703600National Natural Science Foundation of China 82071264Natural Science Foundation of Beijing Municipality 7214256UMHS-PUHSC Joint Institute for Translational and Clinical Research BMU2019JI009
6 · The paper itself

Abstract

Hypomyelinating leukodystrophies (HLDs) are genetic disorders characterized by deficient myelination. While TMEM63A variants are associated with HLD19, the specific lipid alterations in affected brain regions remain to be fully characterized. This study aimed to investigate the spatial distribution of lipid changes in a Tmem63a mutant rat model of hypomyelination. A homozygous Tmem63a c.500G > A p.(G167E) knock-in rat model (Tmem63a

Indexed as

Demyelinating DiseasesLipid MetabolismLipidomicsLipidsMutationMyelin SheathAnimalsBrainDisease Models, AnimalMaleRatsLipidsHypomyelinationMALDI-MSISpatial lipidomicsTMEM63A mutation

Identifiers

PMID41272208
PMCPMC12638909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.