Evidence map›Paper›PMID 41272180›Full record

ArticleArchives of toxicology2026

Genetic variants in VEGF gene family enhance colorectal cancer susceptibility via modulating metabolic pathways.

Yutao Zhou, Zhutao Ding, Yichu Chen, Qian Gong, Bingxin Liu, Yu Shao, Silu Chen, Meilin Wang, Dongying Gu, Junyi Xin

Abstract read
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In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yutao Zhou *The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China.
Zhutao Ding *The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China.
Yichu ChenThe Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China.
Qian GongDepartment of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.
Bingxin LiuThe Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China.
Yu ShaoKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.
Silu ChenThe Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China.
Meilin WangThe Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China. mwang@njmu.edu.cn.
Dongying GuDepartment of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. dygu@njmu.edu.cn.
Junyi XinDepartment of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China. junyixin@njmu.edu.cn.ORCID 0000-0001-6677-3936

Funding

Natural Science Foundation of Jiangsu Province BK20240524
6 · The paper itself

Abstract

The genes belonging to vascular endothelial growth factor (VEGF) family played critical roles in tumor angiogenesis and the activation of signaling pathways associated with cancer promotion. However, it remains unclear whether genetic variants within VEGF gene family could influence the development of colorectal cancer. Here, we utilized the genotyping data from 1150 colorectal cancer patients and 1342 healthy controls to evaluate the associations between single nucleotide polymorphisms (SNPs) within VEGF gene family and the risk of colorectal cancer. Notably, the C allele of VEGFA rs6899540 was significantly associated with an increased colorectal cancer risk after false discovery rate (FDR) adjustment [odds ratio (OR) = 1.61, 95% confidence interval (CI): 1.25-2.06, P = 1.80 × 10

Indexed as

Colorectal NeoplasmsGenetic Predisposition to DiseaseMetabolic Networks and PathwaysVascular Endothelial Growth Factor AAgedCase-Control StudiesFemaleGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideVascular Endothelial Growth Factor AVEGFA protein, humanColorectal cancerGenetic variantMetabolic pathwaysVEGF family

Identifiers

PMID41272180

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.