Evidence map›Paper›PMID 41272165›Full record

ArticleNature immunology2025

Interferon-mediated NK cell activation increases cytolytic activity against T follicular helper cells and limits antibody response to SARS-CoV-2.

Izumi de Los Rios Kobara, Radeesha Jayewickreme, Madeline J Lee, Aaron J Wilk, Stanford COVID-19 Biobank, Andra L Blomkalns, Kari C Nadeau, Samuel Yang, Angela J Rogers, Catherine A Blish

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  2. HLA-E-restricted SARS-CoV-2 epitopes drive CD8Journal of translational medicine · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Izumi de Los Rios KobaraDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6479-110X
Radeesha JayewickremeDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Madeline J LeeDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5039-6806
Aaron J WilkDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1430-5852
Stanford COVID-19 Biobank
Andra L BlomkalnsDepartment of Emergency Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Kari C NadeauDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2146-2955
Samuel YangDepartment of Emergency Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Angela J RogersDivision of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6969-6200
Catherine A BlishDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA. cblish@stanford.edu.ORCID http://orcid.org/0000-0001-6946-7627

Funding

MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OP1113682Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1113682NIAID NIH HHS T32 AI007290
6 · The paper itself

Abstract

Natural killer (NK) cells are innate lymphocytes known for their ability to kill infected or malignant cells, but they have an overlooked role in regulating antibody responses. In mice, NK cells can kill T follicular helper (T

Indexed as

Antibodies, ViralAntibody FormationCOVID-19InterferonsKiller Cells, NaturalLymphocyte ActivationSARS-CoV-2T Follicular Helper CellsAdultCytotoxicity, ImmunologicFemaleHumansMaleNK Cell Lectin-Like Receptor Subfamily KAntibodies, ViralInterferonsNK Cell Lectin-Like Receptor Subfamily K

Identifiers

PMID41272165
PMCPMC12643942

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.