Evidence map›Paper›PMID 41272159›Full record

ArticleScientific reports2025

Periodontitis and renal function decline in type 2 diabetes: a prospective cohort study.

Risako Mikami, Koji Mizutani, Miho Ishimaru, Isao Minami, Daisuke Kido, Kohei Takeda, Hiromi Kominato, Natsumi Saito, Shu Takemura, Keita Nakagawa and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Risako MikamiDepartment of Advanced Biomaterials, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Koji MizutaniDepartment of General Dentistry, Graduate School of Medical and Dental Sciences, Tokyo, Japan. mizutani.peri@tmd.ac.jp.
Miho IshimaruDepartment of Dental Public Health, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Isao MinamiDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Daisuke KidoDepartment of General Dentistry, Graduate School of Medical and Dental Sciences, Tokyo, Japan.
Kohei TakedaHigashi Sakura Dental Clinic, Aichi, Japan.
Hiromi KominatoDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Natsumi SaitoDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Shu TakemuraDepartment of General Dentistry, Graduate School of Medical and Dental Sciences, Tokyo, Japan.
Keita NakagawaDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Koichiro MatsuoDepartment of Oral Health Sciences for Community Welfare, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Yuichi IzumiDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Yoshihiro OgawaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takanori IwataDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Funding

Ministry of Education, Culture, Sports, Science and Technology 16K20666Ministry of Education, Culture, Sports, Science and Technology 23K16014
6 · The paper itself

Abstract

This study aimed to investigate the effect of periodontitis on renal function in patients with type 2 diabetes mellitus (T2D) and to explore the potential underlying pathways. A cohort of 73 patients with poorly controlled T2D who received diabetes care was monitored for six months. The association between the changes in renal function and periodontal parameters at baseline was assessed using regression analysis. Causal mediation analysis was performed to examine the effect of periodontitis on renal function mediated by glycemic control. Of the participants, 57 (78.0%) had stage III or IV periodontitis. Hemoglobin A1c levels improved significantly, from 9.5 ± 1.9% to 7.6 ± 1.4% while estimated glomerular filtration rate (eGFR) declined from 76.8 ± 23.7 to 71.8 ± 21.6 mL/min/1.73 m

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesKidneyPeriodontitisAgedFemaleGlomerular Filtration RateGlycated HemoglobinHumansMaleMiddle AgedProspective StudiesGlycated HemoglobinCausal mediation analysisDiabetes mellitus type 2Diabetic nephropathiesGlomerular filtration ratePeriodontitis

Identifiers

PMID41272159
PMCPMC12638993

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.