ArticleHypertension research : official journal of the Japanese Society of Hypertension2026
Impact of annual health check-ups on improvement in hypertension and abnormalities of glucose and lipid metabolism.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study evaluated the 1-year improvement in blood pressure (BP), glucose metabolism (GM), and lipid metabolism (LM) abnormalities detected during health check-ups, and identified factors associated with improvement. This retrospective cohort study used data from a University Health Care Centre between April 2008 and March 2023. Adults with BP, GM, or LM abnormalities at baseline who attended the following year's check-ups were included. The abnormalities were defined according to the criteria of the Japan Society of Ningen Dock. The primary outcome was improvement in abnormalities at the subsequent check-up, defined as no longer meeting the abnormality criteria. Multivariable logistic regression was used to examine factors associated with improvement. We analysed 2727 participants with BP abnormalities (mean age: 55.4 ± 9.0 years; 71.1% males), 1506 with GM (55.8 ± 8.5 years; 74.9% males), and 3793 with LM (52.4 ± 8.7 years; 61.0% males). Improvement occurred in 57.4% (BP), 29.3% (GM), and 57.5% (LM). Use of corresponding medication at baseline (odds ratios [ORs]: 0.38, 0.33, and 0.14, for BP, GM, and LM, respectively, p < 0.05) and 1-year weight loss (ORs: 1.08, 1.24, and 1.12, respectively, p < 0.05) were associated with improvement across all three domains, whereas use of corresponding medication at the subsequent check-up was associated with improvement in BP and LM (ORs: 2.22 and 14.97, respectively, p < 0.001). In this large health check-up cohort, over half of BP and LM, and approximately one-third of GM abnormalities improved within 1 year. Associations between improvement and both weight reduction and pharmacological treatment highlight the importance of lifestyle modification and timely medical management.
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