ArticleCommunications biology2025
Machine learning predicts lifespan and suggests underlying causes of death in aging C. elegans.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Machine Learning-Accelerated Analysis ofResearch square · 2026Article
- Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging.bioRxiv : the preprint server for biology · 2026Article
- A comprehensive review of artificial intelligence as a catalyst in aging research: insights, gaps and future perspectives.Frontiers in aging · 2026Review
- A hierarchy of causes of death in senescentbioRxiv : the preprint server for biology · 2025Article
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Authors and funding
10 authors.
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Abstract
Aging leads to age-related pathology that causes death, and genes affect lifespan by determining such pathology. Here we investigate how age-related pathology mediates the effect of genetic and environmental interventions on lifespan in C. elegans by means of a data-driven approach employing machine learning (ML). To this end, extensive data on how diverse determinants of lifespan (sex, nutrition, genotype, mean lifespan range: 7.5 to 40 days) affect patterns of age-related pathology was gathered. This revealed that different life-extending treatments result in distinct patterns of suppression of senescent pathology. By analysing the differential effects on mid-life pathology levels and lifespan, the ML models developed were able to predict lifespan variation, explaining 79% of the variance. Levels of pathology in the pharynx and intestine proved to be the strongest predictors of lifespan. This suggests that elderly C. elegans die predominantly from late-life disease affecting these organs. In addition, we noted profound sex differences in age-related pathology: the striking age-related pathologies in hermaphrodites affecting organs linked to reproduction are absent from males, suggesting that reproductive death may be hermaphrodite limited.
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