Evidence map›Paper›PMID 41272077›Full record

ArticleScientific reports2025

Spinal cord neuromodulation for blood pressure control using low-intensity focused ultrasound.

Angelica F Lopez, Denis Routkevitch, Patrick J Kramer, Neil A Babu, Ritvik Jillala, Ananya Tandri, Zoe Soulé, Emily C Baca, A Daniel Davidar, Vikas N Vattipally and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Angelica F LopezDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Denis RoutkevitchDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Patrick J KramerHEPIUS Innovation Lab, Johns Hopkins University, Baltimore, MD, USA.
Neil A BabuDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Ritvik JillalaHEPIUS Innovation Lab, Johns Hopkins University, Baltimore, MD, USA.
Ananya TandriDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Zoe SouléDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Emily C BacaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
A Daniel DavidarHEPIUS Innovation Lab, Johns Hopkins University, Baltimore, MD, USA.
Vikas N VattipallyHEPIUS Innovation Lab, Johns Hopkins University, Baltimore, MD, USA.
Pierce L PerkinsDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Siddharth KrishnanHEPIUS Innovation Lab, Johns Hopkins University, Baltimore, MD, USA.
Ryan S BohluliDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Charles G EberhartDepartment of Clinical and Laboratory Pathology, Johns Hopkins University, Baltimore, MD, USA.
Betty M TylerDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Nicholas TheodoreDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Nitish V ThakorDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Amir ManbachiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. amir.manbachi@jhu.edu.

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Consequences of Cardiac Arrest: Brain InjuryR01HL071568 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GEOCADIN, ROMERGRYKO, THAKOR, NITISH VYOMESH · 2003 to 2022
$8.4M
Institutional Career Development CoreKL2TR003099 · NCATS · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2019 to 2023
$7.9M
Translational Technologies for Ameliorating Brain InjuryR01HL139158 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KANNAN, SUJATHA, THAKOR, NITISH VYOMESH · 2018 to 2021
$2.1M
Spinal Cord Injury: A Cardiovascular Perspective using UltrasoundF30HL168823 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Denis Routkevitch · 2024 to 2026
$164k
NCATS NIH HHS KL2 TR003099NHLBI NIH HHS F30 HL168823NHLBI NIH HHS R01 HL071568NHLBI NIH HHS R01 HL139158NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Focused ultrasound (FUS) is an innovative technology that delivers angled acoustic energy to a small target region. Previous FUS technology has demonstrated efficacy in applications such as tumor destruction, nerve modulation, and drug delivery in the brain. We investigated the effects of low-intensity FUS (LIFU) stimulation on the spinal cord and its ability to regulate mean arterial pressure (MAP). We found that LIFU stimulation on exposed rat spinal cord could modulate MAP, causing a decrease when applied at a lower thoracic level and an increase when applied at a lumbosacral level. We also found that shorter stimulation periods (30 s) were more effective in inducing a decrease in MAP than more extended stimulation periods (90 s). The time required to return to baseline for MAP was shown to increase with subsequent periods of FUS stimulation. FUS could enable non-pharmacological, spatially targeted MAP control, especially for impaired patients. Future applications of FUS neuromodulation extend into solutions for clinical blood pressure disorders, such as autonomic dysreflexia or chronic hypertension.

Indexed as

Blood PressureSpinal CordSpinal Cord StimulationAnimalsHypertensionMaleRatsRats, Sprague-DawleyBlood pressureFocused ultrasoundMean arterial pressureNeuromodulationSpinal cordStimulation

Identifiers

PMID41272077
PMCPMC12638816

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.