ArticleScientific reports2025
Comparative proteomic analysis of Porphyromonas gingivalis challenged human dental pulp stem cells.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental pulp stem cells (DPSCs) are increasingly recognised for their potential in regenerative medicine, particularly in oral and maxillofacial surgeries. However, the unique microbial environment of the oral cavity necessitates a better understanding of how bacterial challenges may affect DPSC function to optimise their reparative capabilities and potential clinical/therapeutic use. This study focused on identifying and understanding differentially expressed proteins in response to Porphyromonas gingivalis challenge and utilises comparative proteomic methodology of the secretome and whole cell lysates with deeper analysis of differentially expressed proteins using STRINGDB and REACTOME databases to elucidate key proteins and networks. This study identified significant proteomic changes in human DPSCs in response to Pg infection, particularly in growth factor signalling, immune response, and wound healing. These insights advance our understanding of DPSC-pathogen interactions, promoting their potential for regenerative and immunomodulatory therapies against infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.