ArticleScientific reports2025
A controlled comparative study on the effect of arterial occlusion pressure on immediate sympathetic and hyperemic responses.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- What Does the Photoplethysmography Add to Laser Doppler Flowmetry During the Brachial Artery Occlusion Test?Journal of biophotonics · 2026Article
- Effects of Repeated Contrast Therapy on Forearm Microcirculatory and Neuromechanical Recovery After Climbing-Specific Fatigue in Amateur Climbers: A Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Influence of Time of Day on Skin Microvascular Response to Post-Occlusive Reactive Hyperemia.Journal of clinical medicine · 2026Article
- Homeostatic Responses to Subsystolic Arterial Occlusive Pressure in Glabrous and Non-Glabrous Skin Circulation.Biomedicines · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different levels of arterial occlusion pressure (AOP) can influence microcirculatory responses and autonomic nervous system activity, potentially affecting individuals undergoing training methods that incorporate AOP, such as blood flow restriction (BFR) training. Therefore, this study aimed to compare the effects of four distinct AOP levels on microcirculatory responses and autonomic nervous system activity-specifically investigating the relationship between post-occlusive reactive hyperemia (PORH), hemodynamic parameters, and heart rate variability (HRV) metrics. This prospective experimental study involved 30 healthy adults who underwent standardized assessments of heart rate variability (HRV) and post-occlusive reactive hyperemia (PORH) across four arterial occlusion pressure (AOP) levels (40, 80, 100, 130%). Measurements were conducted under controlled environmental conditions and consistent body positioning, enabling an analysis of microcirculatory and autonomic responses under progressive vascular occlusion. The results showed no significant changes in resting flow across AOP levels (p = 0.847), while all other parameters-biological zero, peak hyperemia, time to peak, average NN interval, standard deviation of NN intervals, and heart rate-exhibited significant differences between AOP conditions (all p < 0.001, except low frequency to high frequency ratio p < 0.05). However, for most variables, no significant differences were observed between 100 and 130% AOP (p > 0.999), indicating a possible stabilization of physiological responses at higher occlusion pressures. This study concludes that while increasing arterial occlusion pressure significantly affects multiple physiological parameters, responses tend to stabilize between 100 and 130% AOP, suggesting a threshold beyond which further increases yield minimal additional physiological impact.Trial registration trial number ISRCTN15418049.
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