Evidence map›Paper›PMID 41271796›Full record

ArticleNPJ Parkinson's disease2025

Structural and functional brain alterations associated with pain in Parkinson's disease.

Erlei Wang, Yujing Jia, Pubing Yuan, Jin Shi, Yiqing Bao, Yang Ya, Junkang Shen, Aijun Wang, Chengjie Mao, Yuanchao Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Erlei Wang *Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yujing Jia *Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Pubing YuanSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Jin ShiDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Yiqing BaoDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yang YaDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Junkang ShenDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Aijun WangDepartment of psychology, Faculty of Education, Guangxi Normal University, Guilin, China.
Chengjie MaoDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China. drchengjiemao@163.com.
Yuanchao ZhangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. yuanchao.zhang@asu.edu.
Guohua FanDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China. fangh22@126.com.

Funding

Interdiscipline Research Team of Humanities and Social Sciences of Soochow University 2022National Natural Science Foundation of China 82271279Project of Jiangsu Provincial Health Commission M2022063Project of Suzhou Provincial Health Commission SKY2022048Suzhou Key Laboratory SZS2023015the Elderly Health Research Project of Jiangsu Province LKZ2022009the Pre-research Fund project for young Employees of the Second Affiliated Hospital of Soochow University SDFEYLC2243the Science and Technology Project for "Star of Medical Imaging" of Suzhou Medical Association 2022YX-M03the Scientific Research Program of the Xi'an Health Commission 2020QN03the Suzhou Municipal Science and Technology Project SKY2022011the Suzhou Science and Technology Development Plan SKY2022113Xiongan New Area Science and Technology Innovation Project 2023XAGG0073
6 · The paper itself

Abstract

Pain is a common non-motor symptom in Parkinson's disease (PD), but its neural basis remains unclear. This study included 65 PD patients with pain (PDP), 55 without pain (nPDP), and 35 healthy controls (HC), who underwent structural, functional, and diffusion MRI. Both PD groups showed reduced local gyrification index (LGI) in the left anterior insula (aINS) and decreased degree centrality (DC) in the left superior temporal gyrus/temporoparietal junction (STG/TPJ), with greater reductions in PDP. Fractional anisotropy (FA) was reduced in the ventral tegmental area/substantia nigra and bilateral caudate in both PD groups. Functional connectivity between the aINS and STG/TPJ was also reduced. In PDP patients, LGI and FA correlated negatively with pain intensity and positively with each other. These findings may enhance our understanding of the neural mechanisms underlying pain in PD and offer mechanistic insights that could inform the development of more targeted interventions for pain management in this population.

Identifiers

PMID41271796
PMCPMC12749854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.