Evidence map›Paper›PMID 41271795›Full record

ArticleNPJ Parkinson's disease2025

The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson's disease and healthy older adults.

Erik B Erhardt, Andrew R Mayer, Henry C Lin, Sarah E Pirio Richardson, Nicholas A Shaff, Andrei A Vakhtin, Arvind Caprihan, Harm J van der Horn, Natalie Hoffman, John P Phillips and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Glymphatic function in humans: indicators, modulators, and measurement strategies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  2. Review
  3. Article
  4. Engulfment by brain macrophages in a short-lived vertebrate.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Erik B ErhardtDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, USA.
Andrew R MayerDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Henry C LinNew Mexico VA Health Care System, Albuquerque, NM, USA.
Sarah E Pirio RichardsonNew Mexico VA Health Care System, Albuquerque, NM, USA.
Nicholas A ShaffDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Andrei A VakhtinDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Arvind CaprihanDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Harm J van der HornDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Natalie HoffmanDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
John P PhillipsDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Madeleine Grigg-DambergerNene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
Chen-Hsi WangDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Julianna GoughDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA.
Sasha HobsonDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
Amanda DeligtischNene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
Gerson Suarez CedenoNene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
Dana SugarNene and Jamie Koch Comprehensive Movement Disorder Center, Department of Neurology, University of New Mexico, Albuquerque, NM, USA.
Sephira G RymanDepartment of Translational Neuroscience, The Mind Research Network, Albuquerque, NM, USA. sryman@mrn.org.

Funding

Research Education ComponentP30AG086404 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI John Chalmers Adair · 2024 to 2026
$17.7M
Pilot Project Program (PPP)P30GM122734 · NIGMS · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2022
$7.0M
Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseasesR01NS133569 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Sephira Ryman · 2023 to 2026
$3.2M
Cerebrovascular contributions to cognitive impairment in Lewy body dementiasR03AG075408 · NIA · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI RYMAN, SEPHIRA · 2022 to 2023
$362k
NIA NIH HHS P30 AG086404NIA NIH HHS R03 AG075408NIGMS NIH HHS P30 GM122734NINDS NIH HHS R01 NS133569
6 · The paper itself

Abstract

A failure of the glymphatic pathway to clear brain byproducts implicated in neurodegeneration may contribute to the pathophysiology of Parkinson's disease. The glymphatic pathway relies on vasomotion (rhythmic constriction and dilation of blood vessels) to drive cerebrospinal fluid through the interstitial space and clear waste from the brain. The current study demonstrated that intermittent hypercapnia, exposure to low levels of CO

Identifiers

PMID41271795
PMCPMC12638941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.