ArticleNature communications2025
A high signal-to-noise ratio and high-frequency seesaw cantilever for high-speed atomic force microscopy.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- High-speed atomic force microscopy of membrane proteins: From dynamic imaging to integrative structural biology.Current opinion in structural biology · 2026Review
- Fabrication of focused electron beam induced deposition tips for high-speed atomic force microscopy using benchtop scanning electron microscopy.Nature protocols · 2026Review
- Zooming into Disease at the Nanoscale: High-Speed Atomic Force Microscopy in Biomedical Discovery.ACS nano · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The cantilever mediates tip-sample interaction detection in all atomic force microscopes (AFMs). Canonical cantilevers are beams, where length, width, and thickness define the physical properties such as stiffness and resonant frequency, that also mediate laser-reflection to report on cantilever deflection. High-speed AFM (HS-AFM) demands miniaturized cantilevers that are soft and fast, but miniaturized beams reduce laser signal quality. Here, we present a seesaw cantilever with a rigid reflective board oscillating over torsional hinges separating the laser-reflective and mechanical functions. Finite element analysis verified the seesaw mechanism. The board can be optimized for laser-reflection and the shortened distance between tip and hinges enhances the angular sensitivity, while the stiffness is tunable via the hinge dimensions. We detail seesaw cantilever design, fabrication, tip addition, physical equations, and sub-molecular imaging of biological samples. We propose that seesaw cantilevers offer a promising alternative to traditional beam cantilevers for diverse AFM applications.
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Registered trials
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