ArticleNature communications2025
Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Single-cell transcriptomics reveals epithelial-stromal crosstalk underlying fibrotic remodeling in frontal fibrosing alopecia.iScience · 2026Article
- Overview of Short Peptides for Hair Loss.Biomedicines · 2026Review
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Authors and funding
8 authors.
Funding
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Abstract
Homeostasis in continuously renewing organs like the gut, skin, and hair follicles relies on niche architecture and intricately orchestrated cellular dynamics, encompassing proliferation and migration. Here, we develop a 3D live imaging system to map single cell dynamics in micro-dissected human hair follicle segments during anagen phase in ex vivo culture. This approach reveals a spiral-like downward movement of outer root sheath cells entering the lower bulb region. We further mapped upwards flowing cells in the bulb, whose pathways align with differentiation patterns observed for stem cell-derived progenitors in rodent hair follicles. Cell division rates and orientation in the bulb correlate with the velocities of the adjacent upward-moving cell layers, with faster outer layer movement linked to higher mitotic rates. Integrating fluid dynamics simulations and experimental manipulation of mitosis and actin kinetics, we propose a mechanistic model, where a pulling force induced by the outer root sheath contributes to hair fiber extrusion.
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Registered trials
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