ArticleNature communications2025
Lab-in-a-cartridge for real-time detection of tuberculosis via precise measurement of urinary lipoarabinomannan.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Current methods for detecting Mycobacterium tuberculosis (M.tb) in centralized medical facilities are a bottleneck in TB surveillance, particularly in resource-constrained regions. In response, we present a groundbreaking portable bio-tool, the lab-in-a-cartridge (LIC) system, designed for on-site detection of lipoarabinomannan (LAM) in trace amounts within the urine. The innovative design combines pumpless liquid handling and magnetic force-based enrichment with horseradish peroxidase polymer amplification to precisely quantify low biomarker levels. Employing a tetramethylbenzidine-based colorimetric reaction, the LIC enables semi-quantitative LAM detection. This LIC incorporates all necessary reagents, achieving a detection threshold of as low as 0.01 pg/mL in pooled urine samples within 40 minutes. The LIC distinguishes TB patients in clinical urine samples with 92% sensitivity and 88% specificity. This pioneering device not only sets an improved standard for detecting low LAM concentrations but also holds the potential to realize a decentralized diagnosis of TB.
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