Evidence map›Paper›PMID 41271675›Full record

ArticleNature communications2025

Presence of SARS-CoV-2 in fetal organs via intraamniotic infection.

Shengnan Wu, Linchen Tang, Zeying Liu, Meijuan Wu, Xiaoying He, Shanshan Shan, Yicheng Zhou, Ke Lin, Qingxin Xu, Shidong Tan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shengnan Wu *Department of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Linchen Tang *Department of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Zeying Liu *Department of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Meijuan WuDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaoying HeDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Shanshan ShanDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Yicheng ZhouDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Ke LinDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Qingxin XuDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Shidong TanDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Ziyi ZhangDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Yao XuDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-0792-1158
Cancan WangDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Feiye ZhuAcademy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Zhejiang, China.
Zhiyun WeiDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. zhiyun_wei@163.com.ORCID http://orcid.org/0000-0002-3554-4142
Liping JinDepartment of Integrated TCM-WM, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. jinlp01@163.com.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82071653Shanghai Municipal Health Bureau (Shanghai Municipal Public Health Bureau) 2024QN065Shanghai Science and Technology Development Foundation (Shanghai Science and Technology Development Fund) 22ZR1480400Shanghai Science and Technology Development Foundation (Shanghai Science and Technology Development Fund) 23ZR1450400
6 · The paper itself

Abstract

The COVID-19 pandemic underlined the need to focus on women's health, particularly during pregnancy. Recent studies have shown that maternal SARS-CoV-2 infection during pregnancy may increase obstetrical risks. However, intraamniotic SARS-CoV-2 infection has been understudied. Here, we conduct inclusive autopsies on 18 fetuses following maternal SARS-CoV-2 infection to determine whether and which fetal organs can be infected by SARS-CoV-2 in utero. We analyze a total of 538 samples from 32 tissue types to comprehensively map and quantify the distribution and replication patterns of SARS-CoV-2 across fetal organs. Our observations reveal that SARS-CoV-2 can be widely distributed in fetal organs through vertical transmission. As the length of time from SARS-CoV-2 infection to termination of pregnancy increases, the prevalence of infection in fetal organs decrease. Further, proteomic profiling reveals DNA damage and immune imbalance in infected organs.

Indexed as

COVID-19FetusPregnancy Complications, InfectiousSARS-CoV-2AdultAutopsyFemaleHumansInfectious Disease Transmission, VerticalPregnancyProteomics

Identifiers

PMID41271675
PMCPMC12639148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.