Evidence map›Paper›PMID 41271631›Full record

ArticleTranslational psychiatry2025

Effect of polygenic scores on the relationship between psychosis and cognition.

Lauren Varney, Krisztina Jedlovszky, Baihan Wang, Stephen Murtough, Marius Cotic, Alvin Richards-Belle, Noushin Saadullah Khani, Robin Lau, Rosemary Abidoph, Andrew McQuillin and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Lauren VarneyDivision of Psychiatry, University College London, London, UK. lauren.varney.21@ucl.ac.uk.ORCID http://orcid.org/0009-0009-1139-4790
Krisztina JedlovszkyDivision of Biosciences, University College London, London, UK.
Baihan WangDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0000-0001-6986-8236
Stephen MurtoughDivision of Psychiatry, University College London, London, UK.
Marius CoticDivision of Psychiatry, University College London, London, UK.
Alvin Richards-BelleDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0000-0001-8577-9380
Noushin Saadullah KhaniDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0009-0004-6678-4693
Robin LauDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Rosemary AbidophDivision of Psychiatry, University College London, London, UK.
Andrew McQuillinDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0000-0003-1567-2240
Johan H ThygesenInstitute of Health Informatics, Faculty of Population Health Sciences, University College London, London, UK.ORCID http://orcid.org/0000-0002-7479-3459
Psychosis Endophenotypes International Consortium (PEIC)
Genetic Risk and Outcome of Psychosis (GROUP) Investigators
Behrooz Z AlizadehDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-1415-8007
Stephan BenderUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, Cologne, Germany.ORCID http://orcid.org/0000-0001-8199-3785
Benedicto Crespo-FacorroCentre for Biomedical Research in the Mental Health Network (CIBERSAM), Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)-CSIC, Seville, Spain.
Jeremy HallDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-0403-3278
Conrad IyegbeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, USA.
Eugenia KravaritiDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Stephen M LawrieDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2444-5675
Ignacio MataFundación Argibide, Pamplona (Navarra), Spain.
Colm McDonaldClinical Science Institute, University of Galway, Galway, Ireland.ORCID http://orcid.org/0000-0003-1661-5192
Robin M MurrayInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0829-0519
Diana PrataInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-4051-022X
Timothea ToulopoulouDepartment of Psychology & National Magnetic Resonance Research Center (UMRAM), Aysel Sabuncu Brain Research Centre (ASBAM), Bilkent University, Ankara, Turkey.
Neeltje Em van HarenDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0002-3090-7653
Elvira BramonDivision of Psychiatry, University College London, London, UK. e.bramon@ucl.ac.uk.ORCID http://orcid.org/0000-0003-1369-5983

Funding

RCUK | Medical Research Council (MRC) MR/W006774/1RCUK | Medical Research Council (MRC) MR/W020238/1
6 · The paper itself

Abstract

Cognitive impairment is an important but often under-researched symptom in psychosis. Both psychosis and cognition are highly heritable and there is evidence of a genetic effect on the relationship between them. Using samples of adults (N = 4 506) and children (N = 10 981), we investigated the effect of schizophrenia and bipolar disorder polygenic scores on cognitive performance, and intelligence and educational attainment polygenic scores on psychosis presentation. Schizophrenia polygenic score was negatively associated with visuospatial processing in adults (beta: -0.0569; 95% confidence interval [CI]: -0.0926, -0.0212) and working memory (beta: -0.0432; 95% CI: -0.0697, -0.0168), processing speed (beta: -0.0491; 95% CI: -0.0760, -0.0223), episodic memory (betas: -0.0581 to -0.0430; 95% CIs: -0.0847, -0.0162), executive functioning (beta: -0.0423; 95% CI: -0.0692, -0.0155), fluid intelligence (beta: -0.0583; 95% CI: -0.0847, -0.0320), and total intelligence (beta: -0.0458; 95% CI: -0.0709, -0.0206) in children. Bipolar disorder polygenic score was not associated with any cognitive domains studied. Lower polygenic scores for intelligence were associated with greater odds of psychosis in adults (odds ratio [OR]: 0.886; 95% CI: 0.811-0.968). In children, lower polygenic scores for both intelligence (OR: 0.829; 95% CI: 0.777-0.884) and educational attainment (OR: 0.771; 95% CI: 0.724-0.821) were associated with greater odds of psychotic-like experiences. Our findings suggest that polygenic scores for both cognitive phenotypes and psychosis phenotypes are implicated in the relationship between psychosis and cognitive performance. Further research is needed to determine the direction of this effect and the mechanisms by which it occurs.

Indexed as

Bipolar DisorderCognitionCognitive DysfunctionIntelligenceMultifactorial InheritancePsychotic DisordersSchizophreniaAdolescentAdultChildEducational StatusFemaleHumansMaleMemory, Short-TermMiddle Aged

Identifiers

PMID41271631
PMCPMC12638944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.