Evidence map›Paper›PMID 41271593›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Advanced Therapeutic Approach Based on LDHs-Mimetic Oxidoreductase.

Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Advanced Therapeutic Approach Based on LDHs-Mimetic Oxidoreductase.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kai SongTechnical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Yu WeiTechnical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Peng JiaTechnical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Shan HeKey Laboratory of Geriatric Nutrition and Health, Ministry of Education, Technology and Business University, 11 Fucheng Road, Haidian District, Beijing, 100048, P. R. China.
Qian WangTechnical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Manman XuDepartment of Geriatrics, Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, P. R. China.
Hongzhi LiuKey Laboratory of Geriatric Nutrition and Health, Ministry of Education, Technology and Business University, 11 Fucheng Road, Haidian District, Beijing, 100048, P. R. China.
Pengtao BaoThe Eighth Medical Center, Chinese PLA General Hospital, Beijing, 100089, P. R. China.
Shanyue GuanTechnical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.ORCID https://orcid.org/0000-0001-9842-7982
Xiaozhong QuCollege of Materials Science and Opto-Electronic Technology, University of the Chinese Academy of Sciences, Beijing, 101408, P. R. China.

Funding

Beijing Natural Science Foundation 7244312Cross-Innovation Open Project of Food Flavor and Health, Beijing Technology & Business University FFHCI-2025076National Natural Science Foundation of China 21805293 32472269Youth Innovation Promotion Association of Chinese Academy of Sciences 2019027
6 · The paper itself

Abstract

Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis. The precise targeting and sophisticated modulation of redox processes within pathological microenvironments thus offer a promising avenue for innovative therapeutic strategies. Layered double hydroxides (LDHs)-based nanozyme lies in the programmable multi-active site architecture, which enables unprecedented functional integration for precise pathological microenvironment remodeling. In this review, the redox modulating mechanisms of LDHs-based nanozyme in these critical disease contexts are systematically explored, with special emphasis on intrinsic enzyme-like activities and structure-activity relationships. At the same time, it highlights how designing LDHs-based nanozyme can manipulate redox homeostasis to precisely reprogram the pathological microenvironment for stimulating effective, context-dependent pro- and anti-inflammatory therapeutic outcomes, which is a crucial requirement in conditions such as tumors and tissue injury. Finally, building upon recent advances, a forward-looking perspective is provided on the current challenges and future research directions in this rapidly progressing field.

Indexed as

OxidoreductasesAnimalsHumansNeoplasmsOxidation-ReductionOxidoreductasesLDHs−based nanozymepathological microenvironmentredox process

Identifiers

PMID41271593
PMCPMC12822398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.