Evidence map›Paper›PMID 41271585›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Cinnamic-Hydroxamic-Acid Derivatives Exhibit Antibiotic, Anti-Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid-Associated Protein HU.

Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Huan ChenDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.
Yingqi XuDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom.
Zhaoping XiongLaboratory of Health Intelligence, HW Cloud Computing Technologies Co., Ltd, Guizhou, China.
Hongliang WangDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.
Xin WangDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.
Yue KangDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.
Zhonglin WangKey Laboratory of Surgical Critical Care and Life Support, BioBank, Shaanxi Engineering Research Center for Biobank and Advanced Medical Research, Department of Cardiology, Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710041, China.
Xiaoyan ZengKey Laboratory of Surgical Critical Care and Life Support, BioBank, Shaanxi Engineering Research Center for Biobank and Advanced Medical Research, Department of Cardiology, Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710041, China.
Yahui LiuDepartment of Pathogen Biology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yehuan ZhengDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.
Wei ChenDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.
Mengzhe LiCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100089, China.
Zhenyue HuDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.
Chi XuLaboratory of Health Intelligence, HW Cloud Computing Technologies Co., Ltd, Guizhou, China.
Yue WuKey Laboratory of Surgical Critical Care and Life Support, BioBank, Shaanxi Engineering Research Center for Biobank and Advanced Medical Research, Department of Cardiology, Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710041, China.
Yawen WangDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.
Zuyi YuanKey Laboratory of Surgical Critical Care and Life Support, BioBank, Shaanxi Engineering Research Center for Biobank and Advanced Medical Research, Department of Cardiology, Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, 710041, China.
Shuai YuanKey Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Huadong LiuSchool of Life Science and health, University of Health and Rehabilitation Sciences, Qingdao, 266113, China.
Steve MatthewsDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, Exhibition Road, London, SW7 2AZ, United Kingdom.
Nan QiaoLaboratory of Health Intelligence, HW Cloud Computing Technologies Co., Ltd, Guizhou, China.
Yan LiDepartment of Pathogen Biology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Bing LiuDepartment of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, 1st Affiliated Hospital, Xi'an, Shaanxi, 710041, China.ORCID https://orcid.org/0000-0003-1670-6115

Funding

Hubei Natural Science Fund for Distinguished Young Scholars 2022CFA068National Key R&D Program of China 2021YFA1301201National Natural Science Foundation of China 32270151National Natural Science Foundation of China 82172299National Natural Science Foundation of China 82272377
6 · The paper itself

Abstract

Finding novel compounds and drug targets is crucial for antibiotic development. The nucleoid-associated protein HU plays a significant role in bacterial DNA metabolism, supercoiling, and biofilm formation, making it a promising new target. In this work, structure-based screening and identified cinnamic-hydroxamic-acid derivatives (CHADs) are conducted as HU inhibitors, with a minimum inhibitory concentration (MIC) of as low as 12 µg mL

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBiofilmsCinnamatesDNA-Binding ProteinsAnimalsDNA, SuperhelicalMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial ProteinsCinnamatesDNA-Binding ProteinsDNA, Superhelicalbacterial antibiotic resistancebiofilmcinnamic‐hydroxamic‐acid derivativesDNA supercoilingHU

Identifiers

PMID41271585
PMCPMC12955902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.