Evidence map›Paper›PMID 41271562›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Targeting the Notch1-YY1-ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8

Ke Zhu, Fa-Peng Zhang, Chao Qin, Zhi-Xiao Song, Cai-Ni Yang, Shu-Sheng Lin, Xian-Huan Yu, Wen-Rui Wu, Chao-Qun Liu, Chao Liu and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ke ZhuGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Fa-Peng ZhangGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Chao QinScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, China.
Zhi-Xiao SongGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Cai-Ni YangGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Shu-Sheng LinGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Xian-Huan YuGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Wen-Rui WuGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Chao-Qun LiuGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Chao LiuGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Lei-Bo XuGuangzhou Key Laboratory of Precise Diagnosis and Treatment of Biliary Tract Cancer, Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

Funding

Guangdong Provincial Medical Science and Technology Research Foundation A2025158Guangzhou Key Laboratory of Organ Transplantation 2025A03J4036Major Clinical Technology Program of Guangzhou Municipal Health Commission 2023P-ZD17National Natural Science Foundation of China 82173229National Natural Science Foundation of China 82472903Sun Yat-Sen Memorial Hospital Clinical Research 5010 Program SYS-5010-202305Sun Yat-sen Pilot Scientific Research Fund SYSQH-II-2024-05Sun Yat-Sen University Clinical Research 5010 Program 2018008
6 · The paper itself

Abstract

Immunotherapy has shown a modest clinical benefit in advanced hepatocellular carcinoma (HCC), probably due to tumor immunosuppressive functions. Although Notch1 signaling has been implicated in tumor immune escape, its underlying mechanism is unclear. Here, Notch1 signaling is established as a determinant of immunotherapy efficacy in HCC. Studies showed that high Notch1 expression correlates with poor progression-free survival and worse immunotherapeutic response in recurrent HCC patients, while Notch1 overexpression promotes cancer cell escape by inhibiting CD8

Indexed as

Carcinoma, HepatocellularCD8-Positive T-LymphocytesImmunotherapyIntercellular Adhesion Molecule-1Liver NeoplasmsPyroptosisReceptor, Notch1YY1 Transcription FactorAnimalsCell Line, TumorFemaleHumansMaleMiceSignal TransductionICAM1 protein, humanIntercellular Adhesion Molecule-1NOTCH1 protein, humanReceptor, Notch1YY1 protein, humanYY1 Transcription Factorhepatocellular carcinomasNotch1pyroptosistumor‐specific CD8+ T cellsYY1

Identifiers

PMID41271562
PMCPMC12866794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.