Evidence map›Paper›PMID 41271430›Full record

Observational studyHuman vaccines & immunotherapeutics2025

Vaccination status in children with congenital heart disease in Wuxi, China: Analysis of retrospective data.

Lingling Wang, Xu Yang, Shixin Xiu, Guanjie Chen, Xuwen Wang, Yuan Shen

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lingling WangDepartment of Immunization, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Xu YangDepartment of Immunization, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Shixin XiuDepartment of Immunization, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Guanjie ChenDepartment of Information, Statistics and Information Center of Wuxi Health Commission, Wuxi, China.
Xuwen WangDepartment of Immunization, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Yuan ShenDepartment of Immunization, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination rates among children with congenital heart disease (CHD) remain suboptimal. This study aimed to evaluate the epidemiological characteristics, vaccine coverage, and occurrence of adverse events following immunization (AEFIs) of children aged ≤6 y with CHD in Wuxi, China. The medical records of children with CHD who visited grade II and above medical institutions in Wuxi from 2022 to 2023 were collected from the Wuxi Health Information Platform. Vaccination data were retrieved from the Jiangsu Province Vaccination Integrated Service Management Information System. AEFI data were obtained from the National Vaccination Management Information System. Of the 4,267 children enrolled in this study, the top three causes of CHD were atrial septal defect, ventricular septal defect, and patent ductus arteriosus. The proportion of subjects who were administered the vaccine doses of the National Immunization Program (NIP) by the age of 1 year was 81.91-90.34%, whereas the proportion receiving the five non-NIP vaccines was 11.30-37.78%. The rates of AEFIs, general reactions, and abnormal reactions were 7.86, 6.90, and 0.96 cases per 10,000 children aged ≤6 y, respectively. No severe vaccine reactions were observed, and there was no significant difference in the occurrence of abnormal reactions as compared to the general population of children. The proportion of children with CHD receiving the NIP vaccines was relatively high, while the proportion administered the non-NIP vaccines was relatively low. Routine vaccination is safe for the majority of this patient population.

Indexed as

Drug-Related Side Effects and Adverse ReactionsHeart Defects, CongenitalImmunization ProgramsVaccination CoverageVaccinesChildChild, PreschoolChinaCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleVaccinesadverse reactionCongenital heart diseaseimmunization strategyvaccination statusvaccine safety

Identifiers

PMID41271430
PMCPMC12645871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.