ArticleCancer medicine2025
Epidemiology and Prognostic Role of HPV Infection in Head and Neck Cancer: A Population-Based Study of the SEER Database.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- The current role of immunotherapy in treating nasopharyngeal carcinoma.Human vaccines & immunotherapeutics · 2026Review
- Diagnosis, Management, and Follow-Up of Human Papillomavirus Type 16 (HPV-16) Lesions in the Oral Cavity.Cureus · 2026Article
- Epidemiology and Prognostic Role of HPV Infection in Head and Neck Cancer: A Population-Based Study of the SEER Database.Cancer medicine · 2025Article
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Abstract
backgroundHead and neck cancer (HNC) comprises a heterogeneous group of malignancies with significant variation in epidemiology, clinical features, and treatment responses. However, large-scale data on the clinical epidemiology of HNC and the prognostic impact of human papillomavirus (HPV) infection have not yet been reported. MATERIAL AND
methodsData on HNC cases with known HPV status were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Clinical characteristics of HNC were summarized based on HPV status, primary site, and metastatic site. To elucidate the prognostic role of HPV status in HNC, we calculated the relative survival rate (RSR) and conducted Cox regression analysis following propensity score matching by HPV status.
resultsA total of 14,855 HNC cases were included in this study, comprising 10,128 HPV-positive and 4727 HPV-negative cases. Clinical characteristics varied based on HPV status, primary site, and metastatic site. HPV positivity was generally associated with better prognosis, except in cases of nasopharyngeal carcinoma and cancers originating from the gum, as indicated by RSRs. Subgroup Cox regression analysis demonstrated significantly improved survival for HPV-positive cases compared to their HPV-negative counterparts across most categories.
conclusionHNC encompasses a diverse group of heterogeneous diseases, with HPV positivity generally associated with a better prognosis.
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