ArticleBrain, behavior, and immunity2026
Autophagy activation by the Becn1
Zhuofan Lei, Yun Li, Hui Li, Junfang Wu
Abstract read
In one paragraphArticle in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
4 authors.
Zhuofan LeiDepartment of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yun LiDepartment of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Hui LiDepartment of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Junfang WuDepartment of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: junfang.wu@som.umaryland.edu.
Funding
The new roles of the autophagy-lysosomal pathway in spinal cord injury-mediated dementiaR01NS094527 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI MARTA M LIPINSKI, Junfang Wu · 2016 to 2026
$3.5MDementia Following Spinal Cord Injury: Mechanism and Therapeutic TargetingRF1NS110637 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JAY, STEVEN MICHAEL, WU, JUNFANG · 2019 to 2019
$2.8MThe Function and Mechanisms of Autophagy in Spinal Cord InjuryRF1NS094527 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIPINSKI, MARTA M, WU, JUNFANG · 2022 to 2022
$2.2MMechanism of Inflammatory Related Brain Dysfunction after Spinal Cord InjuryR01NS110635 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI FADEN, ALAN IRA, WU, JUNFANG · 2019 to 2023
$2.2MThe Function and Mechanisms of Voltage-Gated Proton Channel Hv1 in Spinal Cord InjuryR01NS110825 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI WU, JUNFANG · 2020 to 2024
$1.9MNINDS NIH HHS R01 NS094527NINDS NIH HHS R01 NS110635NINDS NIH HHS R01 NS110825NINDS NIH HHS RF1 NS094527NINDS NIH HHS RF1 NS110637
6 · The paper itselfAbstract
Autophagy is essential for maintaining cellular homeostasis, particularly under stress conditions such as neurotrauma. In experimental models of spinal cord injury (SCI), dysregulated autophagy has been closely associated with secondary injury cascades. Our previous work demonstrated that post-injury inflammation is exacerbated by genetic inhibition of autophagy and alleviated by pharmacological enhancement. Emerging evidence also indicates that SCI can induce neuropathological changes in the brain, leading to cognitive impairments; however, the underlying molecular mechanisms remain largely unclear. In this study, we utilized Becn1
Indexed as
AutophagyBeclin-1Neuroinflammatory DiseasesRecovery of FunctionSpinal Cord InjuriesAnimalsDentate GyrusDisease Models, AnimalEncephalitisGene Expression ProfilingLocomotionLysosomesMaleMiceMice, Inbred C57BLMice, Mutant StrainsBeclin-1Becn1 protein, mouseBrainGenetic autophagy enhancementMicrogliaNeurogenesisNeuroinflammationRNA sequencingSpinal cord injury
Identifiers
PMID41271189
PMCPMC12821155
What OpenQuestion holds
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LicenceCC BY-NC
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