ArticleJournal of neuroscience methods2026
Uncertainty in population receptive field estimates revealed by variational qPRF.
Article in Journal of neuroscience methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPopulation receptive field (pRF) modeling is a cornerstone of retinotopic mapping in visual neuroscience, enabling precise mapping of visual stimulus processing in the human brain. However, pRF estimates are influenced by multiple sources of variability, including scanner properties, neurovascular coupling, physiological noise, and task-related factors. Traditionally, these estimates are treated as definitive because quantifying variance has been computationally infeasible. NEW
methodWe introduce qPRF-v, an innovative extension of the qPRF software which computes pRF point estimates over 1,000 times faster than existing packages while preserving goodness-of-fit (Waz et al., 2025a).
resultsLeveraging variational inference, qPRF-v efficiently approximates the posterior variance of pRF model parameters, revealing substantial uncertainty, particularly in parameters governing neural dynamics (e.g., compressive exponent) compared to those defining receptive field centers. COMPARISON WITH EXISTING
methodsTo evaluate the impact of variance quantification, we compared population-level retinotopic maps generated via simple averaging (the prior standard) and R
conclusionsBy directly addressing variability, qPRF-v not only increases the accuracy of retinotopic mapping but also enables more robust, individualized analyses of visual processing. This advancement has profound implications for studying visual function in health and disease, paving the way for personalized neuroscience and improved brain atlases for research and clinical applications.
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