Evidence map›Paper›PMID 41270938›Full record

Trial reportRespiratory medicine2025

A mHealth app for sarcoidosis-associated fatigue: a feasibility randomized control trial.

W Ennis James, Jessica Chandler, Katie Benfield, Samantha Pairet, Maria Hoffman, Martina Mueller, Lillian M Christon

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in management of sarcoidosis-associated fatigue: A narrative review.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

W Ennis JamesMUSC, College of Medicine, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Susan Pearlstine Sarcoidosis Center of Excellence, United States. Electronic address: jamesw@musc.edu.
Jessica ChandlerMUSC, College of Nursing, Department of Nursing, Technology Applications Center for Healthful Lifestyles, United States.
Katie BenfieldMUSC, College of Medicine, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Susan Pearlstine Sarcoidosis Center of Excellence, United States.
Samantha PairetMUSC, College of Nursing, Department of Nursing, Technology Applications Center for Healthful Lifestyles, United States.
Maria HoffmanMUSC, College of Medicine, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Susan Pearlstine Sarcoidosis Center of Excellence, United States.
Martina MuellerMUSC, College of Nursing, Department of Nursing, Technology Applications Center for Healthful Lifestyles, United States; Medical University of South Carolina (MUSC), College of Medicine, Department of Public Health Sciences, United States.
Lillian M ChristonMedical University of South Carolina (MUSC), College of Medicine, Department of Psychiatry & Behavioral Sciences, United States.

Funding

The SPARC App: A Smartphone Application for the Management of Sarcoidosis-Associated FatigueR21EB025525 · NIBIB · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JAMES, WALTER ENNIS · 2020 to 2021
$414k
NIBIB NIH HHS R21 EB025525
6 · The paper itself

Abstract

backgroundSarcoidosis associated fatigue (SAF) is the most reported symptom by sarcoidosis patients and leads to impaired quality of life (QOL). It is strongly associated with stress and negative mood states, and accessible and effective treatments are lacking. mHealth has emerged as a viable platform for QOL self-management interventions. We sought to evaluate the feasibility and preliminary efficacy of a mHealth App, the Sarcoidosis Patient Assessment and Resource Companion (SPARC) App, to improve SAF.

methodsPatients with a fatigue assessment scale (FAS) score ≥22 were randomized to either standard of care or the SPARC App which included modules containing educational videos and breathing awareness meditation (BAM). After completing the education modules, patients were instructed to use the BAM module daily for three months. Primary outcomes of usability and feasibility were assessed at three and six months.

resultsBaseline fatigue and stress scores were similarly elevated in the 49 randomized patients. While usability scores were generally favorable (uMARS functionality 3.7, engagement 3.1), only 40 % of patients in the SPARC group met the pre-defined criteria for adherence. We explored potential sociodemographic influences and key informant interviews provided insight into facilitators/barriers to app use. Fatigue, stress, and QOL scores improved in the SPARC group compared to controls, with a dose-response relationship observed in adherent versus nonadherent patients.

conclusionsOur data suggest mHealth apps may be effective in reducing fatigue and stress and improving QOL in people with sarcoidosis, but deployment of mHealth tools still faces barriers.

Indexed as

FatigueMobile ApplicationsSarcoidosisAdultFeasibility StudiesFemaleHumansMaleMeditationMiddle AgedPatient Education as TopicQuality of LifeSelf-ManagementStress, PsychologicalTelemedicine

Identifiers

PMID41270938
PMCPMC13289145

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.