Evidence map›Paper›PMID 41270896›Full record

ArticleGene2026

Characterization of the gut microbiota in patients with stage III colorectal cancer: A case-control study.

Mahamane T Diakité, Shan Sun, Anou M Somboro, Brehima Diakité, Amadou Koné, Yaya Kassogué, Djeneba Fofana, Saidou Balam, Cheick B Traoré, Aminata Maiga and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mahamane T DiakitéUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali. Electronic address: mahamanetalphidiakite@gmail.com.
Shan SunDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Anou M SomboroUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Brehima DiakitéUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Amadou KonéUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Yaya KassoguéUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Djeneba FofanaUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Saidou BalamUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Cheick B TraoréUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Aminata MaigaUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Bakarou KamatéUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Djibril BaDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Modibo DiarraUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Soungou BoréUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Almoustapha I MaigaUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
Qi DaiDepartment of Medicine at Vanderbilt, University Medical Center, Nashville, TN, USA.
Drew Robert NanniniInstitute for Global Oncology, Northwestern University, Chicago, IL, USA; Preventive Medicine Department, Northwestern University, Chicago, IL, USA.
Jane HollDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Robert MurphyInstitute for Global Oncology, Northwestern University, Chicago, IL, USA.
Lifang HouInstitute for Global Oncology, Northwestern University, Chicago, IL, USA; Preventive Medicine Department, Northwestern University, Chicago, IL, USA.
Anthony FodorDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Mamoudou MaigaUniversity of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali; Institute for Global Oncology, Northwestern University, Chicago, IL, USA; Preventive Medicine Department, Northwestern University, Chicago, IL, USA. Electronic address: mamoudou.maiga@northwestern.edu.

Funding

Infection-Associated Cancer Research Training Program in MaliD43CA260658 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOU, LIFANG, MAIGA, MAMOUDOU · 2021 to 2025
$1.3M
NCI NIH HHS D43 CA260658
6 · The paper itself

Abstract

aimTo conduct a case-control study (pilot study) in Africa (Mali) in comparing the gut microbiota of patients with stage III colorectal cancer (CRC) using next-generation sequencing.

methodsShotgun sequencing was performed to characterize participants' fecal microbiota using Illumina's HiSeq platform. This case-control study involved newly diagnosed CRC patients (n = 23) prior to any treatment initiation, and unrelated healthy controls (n = 24) to elucidate their microbial diversity and relative abundance.

resultsThe findings revealed that the gut microbiota in CRC and in healthy were significantly distinctive according to the PERMANOVA test (R

conclusionDistinct gut microbiome profiles between healthy and CRC were observed. In particular, the findings showed a significant reduction in microbial diversity in stage III CRC. This study provides initial metagenomic data on Malian patients with CRC. It will be used to create a larger cohort to better understand the relationship between CRC and the gut microbiota in the Malian CRC population.

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeAdultAgedBacteriaCase-Control StudiesFecesFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedNeoplasm StagingPilot ProjectsAdvanced stageAfricanColorectal cancerGut microbiomeMali

Identifiers

PMID41270896
PMCPMC12780548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.